TCI
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Description
TCI C1387 2-Chlorobenzoxazole (CAS 615-18-9) is a heterocyclic building block bearing an activated chlorine at the C-2 position of the benzoxazole ring. This chlorine acts as a reliable leaving group, allowing nucleophilic aromatic substitution with amines, alcohols, phenols, and thiols under mild conditions. The resulting 2-substituted benzoxazoles are common structural motifs in medicinal chemistry, agrochemical research, and fluorescent materials. AMI Scientific offers this TCI product in 5 g and 25 g packs to support both exploratory screening and repeated preparative work.
Scientific References
- Decken et al. (2005). Synthesis and characterisation of the first transition metal complex of zoxazolamine (2-amino-5-chlorobenzoxazole): the X-ray crystal structure determination of [ZnCl2(η1-Nbenzoxazole-2-amino-5-chlorobenzoxazole)2]. Journal of Inorganic Biochemistry doi:10.1016/j.jinorgbio.2004.09.003
- Wang et al. (2024). 5-Chlorobenzoxazole as solid additive for efficient organic solar cells. Materials Letters doi:10.1016/j.matlet.2024.136663
- J. Roy et al. (1997). Condensation of 2-Amino-5-chlorobenzoxazole with a-Bromoketones: A Mechanistic Study. HETEROCYCLES doi:10.3987/com-97-7861
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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