TCI C1416 2-[2-(2-Chloroethoxy)ethoxy]ethanol (CAS 5197-62-6) is a short-chain PEG building block with a chloride at one terminus and a hydroxyl at the other. This asymmetry lets researchers perform nucleophilic substitution first and then couple through the free hydroxyl group. It is widely used to prepare hydrophilic linkers, crown ethers, and conjugates that require improved water solubility. AMI Scientific stocks this TCI reagent in 25 g, 100 g, and 500 g pack sizes.
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- ZHOU et al. (2009). SYNTHESIS AND GAS PERMEATION CHARACTERIZATION OF POLY[(2-(2-CHLOROETHOXY) ETHOXY)<SUB>x</SUB><SUP>-</SUP>(TRIFLOROETHOXY)<SUB>2-x</SUB>]PHOSPHAZENE. Acta Polymerica Sinica doi:10.3724/sp.j.1105.2009.00645
- Chen et al. (2001). Synthesis of p‐tert‐Butyl‐calix[6] ‐biscrown‐3 via Intramolecular Ring‐closure of 1,4‐Bis (2‐(2‐chloroethoxy) ethoxy) ‐p‐tert‐butyl‐calix[6]arene. Chinese Journal of Chemistry doi:10.1002/cjoc.20010190318
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