TCI C1548 4-Chloro-3-nitrobenzonitrile is a trifunctional aromatic building block bearing nitrile, nitro, and aryl chloride groups on a single benzene ring. The activating nitro substituent makes the adjacent chlorine highly susceptible to nucleophilic aromatic substitution, allowing controlled introduction of amines, alkoxides, and thiolates. The retained nitrile provides a convenient handle for further conversion into amides, carboxylic acids, amidines, or tetrazoles, while nitro reduction opens routes to benzimidazoles and related heterocycles. AMI Scientific offers this TCI reagent in 5 g and 25 g packs for research, medicinal chemistry, and industrial R&D laboratories.
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