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Description
TCI C2096 1-(Carbamoylmethyl)cyclohexaneacetic Acid is a cyclic aliphatic compound built around a cyclohexane ring carrying two side chains attached to the same carbon atom: an acetic acid group and an acetamide group. This quaternary-carbon architecture is widely recognised as an intermediate along the synthetic route to gabapentin, which gives the material an important position in pharmaceutical chemistry research. Supplied by TCI, it is catalogued under Chemistry > Building Blocks > Non-Heterocyclic Building Blocks and reaches the bench as a ready-to-use synthetic starting material rather than a compound the laboratory must assemble in-house.
As a non-heterocyclic building block, this compound provides a doubly substituted cyclohexane framework that is genuinely demanding to construct from scratch, so working with it removes several early synthetic steps from a project. The property that makes it a preferred choice is the presence of two different functional groups within a single molecule — a carboxylic acid and a primary amide — each of which can be addressed separately. The carboxylic acid group can be esterified, amidated, or reduced, while the amide group can undergo rearrangement or cyclisation to form lactam structures. Because both groups sit on the same quaternary carbon, intramolecular cyclisation is geometrically favoured, and the cyclohexane framework contributes conformational rigidity that is useful in molecular design.
In Indonesian laboratories, this building block is typically encountered in university and institutional research groups working on pharmaceutical chemistry and organic synthesis, as well as in formulation and analytical development settings that need a well-defined reference starting material. It suits laboratories that run multi-step syntheses and prefer to begin from a characterised intermediate rather than build the substituted cyclohexane core themselves, shortening project timelines and improving reproducibility between batches of experimental work.
Laboratory Applications
- Gabapentin-related synthetic research: the compound is a recognised intermediate on the gabapentin route, allowing researchers to enter that pathway at an advanced stage without preparing the quaternary cyclohexane core.
- Lactam and heterocycle construction: the primary amide sits close to the carboxylic acid on the same quaternary carbon, making intramolecular cyclisation to lactam structures geometrically favourable and synthetically efficient.
- Selective carboxylic acid derivatisation: the acid group can be esterified, amidated, or reduced independently of the amide, giving chemists a controllable handle for building diverse derivative libraries.
- Amide-group transformation studies: the primary amide can be subjected to rearrangement or cyclisation chemistry, making the molecule a useful substrate for investigating functional group interconversion under different conditions.
- Conformationally constrained molecule design: the cyclohexane framework imparts rigidity that medicinal and organic chemists exploit when designing target molecules requiring defined three-dimensional shape rather than flexible chains.
Specifications
- Brand: TCI
- Product code: C2096
- CAS number: 99189-60-3
- Chemical name: 1-(Carbamoylmethyl)cyclohexaneacetic Acid
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Pack sizes and storage conditions: as specified on the manufacturer's label and accompanying documentation
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated place, away from direct sunlight, moisture, and incompatible reagents, following the storage conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original supplier container, or transfer it to a clean, chemically resistant, tightly sealed vessel that is clearly labelled with the product name and CAS number. Handle in a fume hood using standard laboratory personal protective equipment, including safety goggles, a laboratory coat, and suitable chemical-resistant gloves. Avoid inhalation of dust and direct skin or eye contact, use clean dry spatulas to prevent contamination between weighings, and dispose of residues and contaminated materials in accordance with applicable institutional and local chemical waste regulations.
