3-(4-Chlorophenyl)propanoic Acid TCI C2177

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Berat 5g 25g

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Description

TCI C2177 3-(4-Chlorophenyl)propanoic Acid is an aliphatic carboxylic acid built on a three-carbon chain whose terminus is attached to a benzene ring carrying a chlorine substituent at the para position. The compound belongs to the family of non-heterocyclic building blocks and is very frequently used as a basic scaffold in the assembly of target molecules in organic synthesis laboratories. Its role is clear: the carboxylic acid group supplies a versatile connection point for the formation of amides, esters, and other acyl derivatives, while the propanoate chain provides the spacing and conformational flexibility needed so that the final molecule can occupy three-dimensional space according to the researcher's design.

The properties that make this material a preferred choice are its high stability under ordinary storage conditions together with the convenience of handling it as a crystalline solid. The solid form makes accurate weighing at the millimole scale straightforward and reduces the risk of spillage compared with liquid reagents. The carboxyl group can be activated with standard coupling reagents, so amidation reactions proceed efficiently with a wide range of amines. Meanwhile, the chlorine atom on the aromatic ring serves a dual function, acting both as a regulator of electronic character and as a modulator of lipophilicity in the resulting structure.

In Indonesian laboratories, this building block is typically used in university organic synthesis groups, research institute chemistry units, and industrial research laboratories that carry out multi-step preparation of target compounds. It fits routine benchwork where researchers need a dependable, well-defined starting fragment that can be weighed out reliably and carried through coupling, esterification, or derivatization steps without special infrastructure beyond a standard synthesis laboratory.

Laboratory Applications

Amide bond formation: the carboxyl group is readily activated with standard coupling reagents, allowing efficient amidation with a broad range of primary and secondary amines.
Ester synthesis and derivatization: the same carboxylic acid handle converts cleanly into esters and other acyl derivatives, giving synthetic chemists several routes from one starting material.
Scaffold construction in multi-step synthesis: the propanoate chain supplies defined spacing and conformational flexibility, letting the target molecule adopt the three-dimensional arrangement the researcher intends.
Electronic and lipophilicity tuning: the para-chlorine substituent on the aromatic ring lets chemists adjust electronic character and lipophilicity of the final structure during design work.
Teaching and method development in organic synthesis: its crystalline solid form supports accurate millimole-scale weighing, making it practical for reproducible small-scale preparations and student exercises.

Specifications

Brand: TCI
CAS number: 2019-34-3
Catalogue code: C2177
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Physical form: crystalline solid
Pack sizes: available in the standard TCI catalogue pack sizes; please confirm the required size when ordering
Storage: stable under ordinary laboratory storage conditions

Handling and Storage

Store the container in a cool, dry place away from direct sunlight and sources of heat or ignition, since the material is stable under ordinary storage conditions and does not require special infrastructure. Keep it in the original tightly closed container, or in a clean, well-sealed glass or chemically compatible plastic vessel that is clearly labelled with the compound name and CAS number. Handle the crystalline solid in a well-ventilated area or fume hood, wearing safety goggles, gloves, and a laboratory coat, and use a clean spatula for weighing to avoid cross-contamination. Close the container promptly after use to limit moisture uptake, and clean up any spilled solid immediately following the laboratory's standard waste-handling procedure. Always consult the manufacturer's safety data sheet before first use.