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Description
TCI C2224 Cefotaxime Sodium Salt is the sodium salt of cefotaxime, a beta-lactam antibiotic belonging to the third-generation cephalosporin class, supplied as a laboratory-grade reagent. The compound works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, which makes it a highly useful test substance in clinical microbiology, antibiotic resistance research, and tissue culture work. Its well-defined mode of action and broad recognition among researchers allow it to serve as a dependable reference antibiotic across a wide range of experimental protocols.
Beyond its role in susceptibility testing panels, cefotaxime sodium is also a mainstay in plant biotechnology laboratories for eliminating Agrobacterium tumefaciens following genetic transformation procedures, without causing any significant adverse effect on the plant tissues being cultured. The key characteristic that makes it so widely chosen is its excellent solubility in water thanks to the sodium salt form, so stock solutions can be prepared quickly and sterile-filtered through a 0.22 micrometre membrane for addition to culture media. Its broad spectrum of activity against Gram-negative bacteria makes it a practical choice for selective media, while its adequate stability toward a number of beta-lactamases adds further value.
In Indonesian laboratories, this reagent finds regular use across university research groups, plant tissue culture facilities, and microbiology testing units. It is commonly incorporated into post-transformation culture media in biotechnology laboratories, and it also supports antibiotic susceptibility work and resistance studies in clinical microbiology settings. Because the sodium salt dissolves readily in water, preparation of working solutions fits easily into routine laboratory workflows, making it a convenient reagent for both teaching laboratories and dedicated research facilities.
Laboratory Applications
Antibiotic susceptibility testing: serves as a third-generation cephalosporin test substance in microbiological panels where a well-characterised beta-lactam reference antibiotic is required for reproducible results.
Agrobacterium elimination in plant tissue culture: removes Agrobacterium tumefaciens after genetic transformation without causing significant adverse effects on the plant tissues being cultured and regenerated.
Antibiotic resistance research: supports investigation of beta-lactamase-mediated resistance mechanisms because the compound offers adequate stability toward a number of beta-lactamase enzymes.
Selective culture media preparation: its broad spectrum of activity against Gram-negative bacteria makes it a practical additive for suppressing unwanted bacterial growth in selective media.
Cell wall synthesis studies: its mechanism of binding penicillin-binding proteins to inhibit bacterial cell wall synthesis makes it a useful tool compound for mechanistic microbiology experiments.
Specifications
Brand: TCI
CAS Number: 64485-93-4
Category: Life Science > Biochemicals and Reagents > Antibiotics
Chemical form: sodium salt of cefotaxime, a beta-lactam antibiotic of the third-generation cephalosporin class
Grade: laboratory-grade reagent
Solubility: readily soluble in water due to the sodium salt form; stock solutions can be sterile-filtered through a 0.22 micrometre membrane
Pack sizes: please refer to the packaging options listed for this catalogue item
Handling and Storage
Store this antibiotic reagent in its original tightly closed container, protected from moisture and kept under the storage conditions indicated on the product label and accompanying documentation. Prepared aqueous stock solutions should be sterile-filtered through a 0.22 micrometre membrane rather than heat sterilised, then dispensed into clean, sealed containers for storage. Handle the material in a well-ventilated area or laminar flow cabinet using standard laboratory personal protective equipment, including gloves, a laboratory coat, and eye protection. Avoid the generation and inhalation of dust during weighing, and use aseptic technique when adding the solution to culture media. Consult the manufacturer's safety data sheet before use and dispose of surplus material according to applicable laboratory waste procedures.
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