TCI
Ceftazidime (contains ca. 10% Na2CO3) TCI C2225
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Description
TCI C2225 Ceftazidime (contains ca. 10% Na2CO3) is a third-generation cephalosporin antibiotic supplied in a formulation together with sodium carbonate, which acts as a dissolution aid. Ceftazidime is well known for its pronounced activity against *Pseudomonas aeruginosa* and a wide range of other Gram-negative bacteria, which makes it an important reagent in microbiological research, antimicrobial susceptibility testing, and plant tissue culture work. Its mechanism of action inhibits the formation of the bacterial cell wall through binding to penicillin-binding proteins, making it a suitable tool for studying differences in response between bacterial species and the resistance patterns that develop in both clinical and agricultural environments.
The presence of approximately 10% sodium carbonate in this product is a characteristic that actually works in favour of the laboratory user, because it helps dissolve ceftazidime, which is naturally poorly soluble in water under neutral conditions. Preparation of high-concentration stock solutions therefore becomes easier and faster, particularly when a researcher needs to add the antibiotic to culture media under sterile conditions. The strong antipseudomonal spectrum of activity, combined with the relative stability of the formulation, is what leads many laboratories to select this presentation over less readily soluble alternatives when reproducible stock preparation matters.
In Indonesian laboratories, this reagent is typically used in university microbiology departments, hospital and clinical research units, and plant biotechnology facilities. It supports routine antimicrobial susceptibility work on Gram-negative isolates, comparative studies of resistance among bacterial species, and the elimination of bacterial contamination in plant tissue culture media. Because stock solutions can be prepared quickly and sterile-filtered into media, it fits the everyday workflow of teaching, research, and applied agricultural laboratories.
Laboratory Applications
- Antimicrobial susceptibility testing — the well-characterised third-generation cephalosporin spectrum allows reliable comparison of Gram-negative isolate responses across routine diagnostic and research testing panels.
- *Pseudomonas aeruginosa* research — the pronounced antipseudomonal activity of ceftazidime makes this reagent particularly suitable for studies focused on this clinically important Gram-negative organism.
- Bacterial resistance pattern studies — inhibition of penicillin-binding proteins provides a defined mechanism against which emerging resistance in clinical and agricultural environments can be systematically examined.
- Plant tissue culture — the antibiotic is added to culture media to suppress Gram-negative bacterial contamination, and the sodium carbonate content simplifies sterile stock solution addition.
- Cell wall biosynthesis studies — because the compound acts by blocking bacterial cell wall formation, it serves as a mechanistic probe for comparing responses between different bacterial species.
Specifications
- Brand: TCI
- CAS number: 72558-82-8
- Category: Life Science > Biochemicals and Reagents > Antibiotics
- Product code: C2225
- Composition: ceftazidime containing ca. 10% Na2CO3 as a dissolution aid
- Pack sizes: please refer to the available packaging options listed for this catalogue item
- Storage: store according to the manufacturer's instructions on the product label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry place, protected from moisture and direct sunlight, and follow the storage conditions stated by the manufacturer on the product label and safety data sheet. Keep the material in its original container or in a clean, well-sealed vial that is clearly labelled. Handle the powder in a fume hood or a well-ventilated area, and wear a laboratory coat, gloves, and eye protection to avoid inhalation of dust or contact with skin and eyes. Prepare stock solutions using aseptic technique and sterile filtration when the material is intended for addition to culture media. Antibiotic residues and unused solutions should be disposed of as laboratory chemical waste in accordance with institutional procedures.
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