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Description
TCI C2242 Cefazolin Sodium Salt is the sodium salt form of cefazolin, a first-generation cephalosporin antibiotic supplied as a biochemical reagent for laboratory research purposes. Like other beta-lactam antibiotics, cefazolin acts by interfering with the formation of the bacterial cell wall. In microbiology laboratories, this compound serves as both a reference material and a test substance across a wide range of experiments, from bacterial susceptibility determination and studies of resistance mechanisms to the development of analytical methods for quantifying antibiotic content in various sample matrices.
The properties that make this material a preferred choice begin with its excellent solubility in water as a sodium salt, which means that test solutions of measured concentration are easy to prepare and can be sterile-filtered without requiring any organic solvent. Its spectrum of activity against Gram-positive bacteria makes it a useful comparator within susceptibility testing panels. As a reagent-grade material, its batch-to-batch consistency helps maintain the repeatability of results, a factor that is decisive in minimum inhibitory concentration testing where small variations in the test substance can shift the endpoint.
In Indonesian laboratories, this material is typically used in university microbiology and pharmacy departments, hospital clinical laboratories, quality control units in the pharmaceutical industry, and research institutes working on antimicrobial resistance. It is available in 5 g and 25 g pack sizes, which suit both routine testing requirements and larger-scale research programmes, allowing a laboratory to match the quantity purchased to the volume of work it actually carries out.
Laboratory Applications
Bacterial susceptibility testing: serves as a reference antibiotic in susceptibility panels, where its known activity against Gram-positive organisms provides a dependable comparator for interpreting test outcomes.
Minimum inhibitory concentration determination: its reagent-grade batch-to-batch consistency supports the repeatability that MIC endpoint work demands, since variation in the test substance directly shifts the measured value.
Resistance mechanism studies: as a beta-laktam-class agent acting on bacterial cell wall formation, it is suitable for investigating how organisms develop and express resistance to cephalosporins.
Analytical method development: used as a test substance when developing and validating methods for the determination of antibiotic content across different sample matrices encountered in routine analysis.
Preparation of aqueous test solutions: its high water solubility as the sodium salt allows accurately measured concentrations to be prepared and sterile-filtered without any organic solvent.
Specifications
Brand: TCI
Product code: C2242
CAS number: 27164-46-1
Category: Life Science > Biochemicals and Reagents > Antibiotics
Pack sizes: 5 g and 25 g
Storage: store according to the conditions stated on the manufacturer's label and product documentation
Handling and Storage
Store the material in its original tightly closed container, following the storage conditions stated by the manufacturer on the product label and accompanying documentation. Keep containers closed when not in use and protect the contents from moisture, as the sodium salt is readily water-soluble. Prepared aqueous solutions should be held in clean, labelled containers and used in line with the laboratory's own procedures. Handle the material in a well-ventilated area using standard laboratory personal protective equipment, including a laboratory coat, gloves, and eye protection, and avoid generating or inhaling dust when weighing out portions. Only trained personnel should handle antibiotic reagents, and all use should remain confined to research and laboratory testing purposes.
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