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Description
TCI C2256 Clindamycin Hydrochloride Monohydrate is the hydrochloride monohydrate salt form of clindamycin, a lincosamide-class antibiotic derived semisynthetically from lincomycin. The compound inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, specifically at a site adjacent to the binding region of macrolide antibiotics. In microbiology laboratories, clindamycin is widely used for antimicrobial susceptibility testing, particularly against anaerobic bacteria and Gram-positive cocci, and for detecting clinically important resistance patterns through specialised agar plate assays.
Several properties make this material a preferred choice for routine laboratory work. Its hydrochloride salt form confers good solubility in water, so stock solutions can be prepared quickly without recourse to organic solvents. The monohydrate form provides a fixed water of crystallisation content, which makes weighing more consistent and concentration calculations more reliable. Its activity is pronounced against anaerobic bacteria such as Bacteroides and Clostridium, as well as against Staphylococcus and Streptococcus species. The ability to suppress bacterial toxin production at subinhibitory concentrations further adds to its value as a study material.
In Indonesian laboratories, this reagent is typically handled in clinical microbiology units, university research laboratories, and pharmaceutical quality control settings where susceptibility profiling and antibiotic research are routine. Its straightforward aqueous preparation suits laboratories that prefer to avoid organic solvent handling, while the defined hydrate form supports reproducible results across operators and across repeat testing runs performed over extended study periods.
Laboratory Applications
Antimicrobial susceptibility testing — the well-defined salt form allows accurate preparation of the graded concentration series required for reliable minimum inhibitory concentration determination.
Anaerobic bacteriology studies — pronounced activity against Bacteroides and Clostridium makes it a standard reference agent when characterising anaerobic isolates in culture.
Gram-positive coccus research — established activity against Staphylococcus and Streptococcus supports comparative work on lincosamide response in these clinically important organism groups.
Resistance pattern detection — used in specialised agar plate assays designed to reveal clinically significant resistance phenotypes that routine broth methods may not disclose.
Bacterial toxin production studies — its capacity to suppress toxin synthesis at subinhibitory concentrations makes it a useful tool compound for investigating virulence expression mechanisms.
Specifications
Brand: TCI
CAS number: 58207-19-5
Category: Life Science > Biochemicals and Reagents > Antibiotics
Chemical form: hydrochloride monohydrate salt of clindamycin, a lincosamide antibiotic
Solubility: soluble in water owing to the hydrochloride salt form
Pack sizes: available in the pack sizes listed for this catalogue item
Handling and Storage
Store the material according to the manufacturer's stated conditions, keeping the container tightly closed in a cool, dry place away from direct light and moisture. Because the monohydrate form carries a defined water of crystallisation content, protecting it from atmospheric humidity helps preserve weighing accuracy. Use clean, dry, chemically resistant containers for storage, and amber glass or opaque vessels for prepared stock solutions. Handle the powder inside a fume hood or a suitably ventilated area, wear gloves, a laboratory coat, and eye protection, and avoid generating dust during weighing. As with all antibiotic substances, minimise skin contact and dispose of residues and contaminated consumables through the laboratory's designated chemical and biological waste routes.
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