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Description
TCI C2257 Clindamycin Phosphate is the phosphate ester of clindamycin, a compound that functions as an inactive prodrug and converts into its active form once the phosphate group is cleaved by phosphatase enzymes. As a lincosamide-class antibiotic, clindamycin acts by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit. In the laboratory setting, this phosphate form is widely used in research on topical and injectable formulation development, pharmaceutical product quality testing, and microbiological studies that require a compound with excellent water solubility.
The principal characteristics that make this material a preferred choice are its far higher water solubility compared with clindamycin base, together with the fact that it produces no bitter taste and causes no tissue irritation before activation. The phosphate group renders the compound stable in aqueous solution across the pH range commonly used in formulation work, which greatly simplifies the preparation of liquid dosage forms and gels. In a research context, this prodrug behaviour is itself an attractive feature, because it allows investigators to examine the relationship between the rate of enzymatic hydrolysis, release of the active substance, and the antibacterial activity observed in experiment.
In Indonesian laboratories, TCI C2257 Clindamycin Phosphate is typically employed by pharmaceutical formulation groups, quality control units, and microbiology laboratories in universities, research institutes, and industry. It supports routine work in developing and evaluating topical and injectable preparations, verifying the quality of finished pharmaceutical products, and carrying out microbiological investigations where a highly water-soluble antibiotic standard is required for reliable and reproducible results.
Laboratory Applications
- Topical formulation research — the very high water solubility and non-irritating character before activation make this phosphate ester well suited to developing gels and other topical preparations for the skin.
- Injectable preparation development — its excellent aqueous solubility and stability in water-based solutions across common formulation pH ranges allow straightforward preparation of liquid dosage forms for study.
- Pharmaceutical quality testing — the material serves as a defined lincosamide antibiotic reference for quality control work on finished pharmaceutical products containing clindamycin phosphate as active ingredient.
- Microbiological studies — as a lincosamide antibiotic acting on the bacterial 50S ribosomal subunit, it supports antibacterial testing where a highly water-soluble compound is required.
- Prodrug activation studies — researchers use it to investigate the relationship between the rate of phosphatase-mediated enzymatic hydrolysis, release of active clindamycin, and observed antibacterial activity.
Specifications
- Brand: TCI
- CAS Number: 24729-96-2
- Category: Life Science > Biochemicals and Reagents > Antibiotics
- Chemical class: lincosamide antibiotic, phosphate ester of clindamycin (inactive prodrug form)
- Pack sizes: available in the standard catalogue pack sizes offered for this TCI item; please refer to the product listing for the options currently available
- Storage: store according to the conditions stated on the manufacturer's label and accompanying safety data sheet
Handling and Storage
Store this product under the conditions specified on the manufacturer's label and in the accompanying safety data sheet, keeping the container tightly closed and protected from moisture, since the material is intended for use as a highly water-soluble reagent. Keep it in its original container or in a comparable well-sealed chemical container, clearly labelled and separated from incompatible substances. Handle the compound in a well-ventilated area using standard laboratory personal protective equipment, including a laboratory coat, gloves, and eye protection. Avoid the generation of dust during weighing and transfer, prepare aqueous solutions with clean glassware, and observe the usual precautions applicable to antibiotic substances, including careful cleaning of work surfaces and appropriate disposal of residues and contaminated consumables.
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