Chromone-3-carbonitrile TCI C3075

Name: TCI C3075 50743-17-4 Chromone-3-carbonitrile
Brand: TCI
SKU: TCI2510C307518020
Price: 1653750.0 IDR
Availability: InStock

Rp 1.653.750,00

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Berat 5g

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Description

TCI C3075 Chromone-3-carbonitrile is a heterocyclic compound built on a chromone (4H-chromen-4-one) core carrying a nitrile group at the 3-position. Chromone is a benzopyranone framework that serves as the structural core of many natural products as well as synthetic bioactive molecules, while the nitrile group adds a reactive site of considerable value to synthetic chemists. In the laboratory, this compound is used as a building block for constructing more complex heterocyclic systems, particularly through annulation reactions, nucleophilic addition, and transformation of the nitrile group into amides, carboxylic acids, amines, or nitrogen-containing rings.

The property that makes this material attractive is its electronic character as an effective Michael acceptor. The chromone carbonyl group at the 4-position, together with the nitrile group at the 3-position, forms an electron-poor unsaturated system, so that the C2–C3 double bond is highly reactive toward nucleophilic attack. Such reactions are often followed by opening of the pyranone ring and reclosure into a new heterocyclic framework, a pathway widely exploited for assembling compound libraries efficiently. The nitrile group also provides a clear infrared spectroscopic marker, which assists chemists in monitoring the progress of a reaction and in confirming the identity of the material.

In Indonesian laboratories, this building block is typically found in university organic synthesis groups, medicinal chemistry research units, and institutional research laboratories developing new heterocyclic scaffolds. It is normally ordered in modest quantities appropriate to exploratory and methodology-driven work, where a small amount of a well-defined starting material supports many reaction trials. Users generally pair it with standard synthetic glassware, inert-atmosphere technique where required, and routine spectroscopic characterization by infrared and NMR to verify the products obtained.

Laboratory Applications

Heterocyclic scaffold construction — the electron-poor C2–C3 double bond and the reactive nitrile together allow annulation reactions that assemble more complex fused ring systems from a single, well-defined starting material.
Michael addition methodology studies — the chromone carbonyl and the 3-nitrile create an effective Michael acceptor, making this compound a reliable substrate for exploring nucleophilic addition scope and selectivity.
Ring-opening and recyclization chemistry — nucleophilic attack is frequently followed by pyranone ring opening and reclosure, giving synthetic chemists direct access to entirely new nitrogen-containing heterocyclic frameworks.
Compound library preparation — because a single set of reaction conditions can generate many structural variants, this building block supports efficient library assembly for medicinal chemistry and screening programmes.
Functional group interconversion practice — the nitrile group can be transformed into amides, carboxylic acids, amines, or nitrogen heterocycles, making it a versatile handle for teaching and for multi-step synthetic route development.

Specifications

Brand: TCI
CAS number: 50743-17-4
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Chemical class: chromone (4H-chromen-4-one) derivative bearing a nitrile group at the 3-position
Pack sizes: available in laboratory research pack sizes; please confirm the current packaging option when ordering
Storage: keep in the closed original container in a cool, dry place away from light and moisture

Handling and Storage

Store TCI C3075 Chromone-3-carbonitrile in its original tightly closed container in a cool, dry, well-ventilated area, protected from direct sunlight, moisture, and sources of heat or ignition. Amber glass or the supplier's original packaging is suitable, and containers should be resealed promptly after each use to limit exposure to atmospheric humidity. Handle the material in a fume hood using safety glasses, chemically resistant gloves, and a laboratory coat, and avoid inhalation of dust or contact with skin and eyes. Weigh out only the quantity needed, keep the compound away from strong oxidizing agents and strong bases, and consult the manufacturer's safety data sheet before first use. Dispose of residues and contaminated materials in accordance with institutional chemical waste procedures.