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Description
TCI D1275, CAS 51721-39-2, is 3-Decyn-1-ol, a homopropargylic alcohol built on a ten-carbon chain carrying a primary hydroxyl group at one end and a triple bond at the third position. The product is supplied as a liquid in a 5 mL pack and belongs to the non-heterocyclic building block group. The single methylene spacer separating the alcohol from the alkyne gives the molecule a synthetic flexibility that differs from propargylic alcohols, allowing researchers to work on either functional group without the two interfering with each other. Its principal laboratory role is to serve as an intermediate on the route toward well-defined long-chain molecules.
The property that most often drives its selection is the position of the triple bond, which sits far enough from the hydroxyl group that electronic communication between the two functionalities remains small. This condition is advantageous when a researcher wants to carry out partial hydrogenation to a cis-alkene, catalytic coupling, or alkylation at the alkyne without disturbing an alcohol group that has already been protected. The long alkyl chain contributes a lipophilic character that approaches the structure of naturally occurring biological compounds, while the primary hydroxyl group is readily oxidised, esterified, or converted into a leaving group for chain extension.
In Indonesian laboratories, this kind of bifunctional building block is typically drawn on in university and institutional research settings where multi-step synthetic sequences are assembled toward defined target molecules. The 5 mL pack suits the scale at which such exploratory and methodological work is normally carried out, allowing several small reactions to be run from a single unit while the material is kept under controlled conditions between uses in a shared organic synthesis facility.
Laboratory Applications
Partial hydrogenation to cis-alkenes: the isolated internal triple bond can be reduced selectively to the Z-alkene geometry needed when constructing defined unsaturated long-chain targets.
Catalytic coupling chemistry: the alkyne unit participates in metal-catalysed coupling reactions, letting researchers join the ten-carbon fragment to another partner in a controlled manner.
Alkylation at the alkyne: the triple bond can be functionalised to extend the carbon framework while a protected hydroxyl group at the far end remains untouched throughout.
Hydroxyl group transformations: the primary alcohol is easily oxidised, esterified, or converted into a leaving group, giving a straightforward handle for further chain extension.
Synthesis of lipophilic bioactive analogues: the long alkyl chain approaches the character of natural biological structures, making it useful for preparing compounds of that structural class.
Specifications
Brand: TCI
CAS number: 51721-39-2
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Product name: 3-Decyn-1-ol (catalogue code D1275)
Pack size: 5 mL
Physical form: liquid
Storage: keep the container tightly closed under the conditions indicated on the manufacturer's label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from heat, open flames, and incompatible materials, following the conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original supplier container, or in a clean, chemically compatible and clearly labelled vessel if transferred, and close it immediately after each withdrawal to limit evaporation and moisture uptake. Handle the liquid inside a fume hood using dry glassware and clean transfer equipment, and wear safety glasses, gloves, and a laboratory coat. Because the pack size is small, dispense only the volume required for each reaction and return the container promptly to its designated storage location. Dispose of residues and contaminated materials through the laboratory's established chemical waste procedures.
