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Description
TCI D1331 Phenytoin Sodium is the sodium salt of 5,5-diphenylhydantoin, a heterocyclic compound built around a hydantoin ring bearing two phenyl groups at the fifth carbon position. In the catalogue it is classified as a heterocyclic building block, meaning a nitrogen-ring starting material used to construct or compare other molecular structures. In the laboratory the compound plays a dual role: as a hydantoin scaffold for synthesis and chemical modification work, and as a very well known reference compound in pharmacology studies, pharmaceutical analysis, and research into sodium ion channels in excitable cells.
The property that makes this sodium salt form the preferred choice is its markedly better water solubility compared with the free acid form. Deprotonation at the imide nitrogen produces a resonance-stabilised anion, so the salt dissolves readily when stock solutions are being prepared. As a consequence, the resulting solutions are basic in character and tend to absorb carbon dioxide from the air, which can slowly precipitate the free acid form back out of solution. The solid is also hygroscopic. The hydantoin ring itself contributes a hydrogen-bonding pattern that is useful in structural and analytical work.
In Indonesian laboratories, this material is typically used in university and institutional research settings where a recognised hydantoin reference compound is needed. It supports pharmaceutical analysis work, method development, and comparison studies, as well as synthetic chemistry projects that begin from a nitrogen-heterocycle framework. Because the salt dissolves easily in aqueous media, it is convenient for laboratories preparing stock solutions for biological or pharmacological experiments under local working conditions.
Laboratory Applications
Heterocyclic synthesis work: the hydantoin core with its two phenyl substituents serves as a defined starting framework for building or modifying related nitrogen-ring molecular structures.
Pharmacological reference studies: the compound is a very well known reference substance, making it suitable when a recognised standard is required for comparison in pharmacology investigations.
Pharmaceutical analysis: the defined hydantoin structure and characteristic hydrogen-bonding pattern support analytical identification and comparison work in pharmaceutical laboratories developing or checking methods.
Sodium ion channel research: the material is widely used as a reference compound in studies of sodium ion channels in excitable cells, where reproducible aqueous solutions are needed.
Aqueous stock solution preparation: because the sodium salt dissolves far more readily than the free acid, it is practical for laboratories preparing solutions for downstream experimental work.
Specifications
Brand: TCI
CAS number: 630-93-3
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Chemical identity: sodium salt of 5,5-diphenylhydantoin (phenytoin sodium)
Physical form: solid, hygroscopic
Pack sizes: available in the pack sizes listed for this catalogue item
Storage note: keep tightly closed and protected from moisture and air
Handling and Storage
Store the solid in a tightly closed container in a dry place, since the material is hygroscopic and will take up moisture from the surrounding air. Keep the original container sealed between uses and minimise the time the bottle stays open on the bench. Prepared solutions are basic and tend to absorb carbon dioxide from the air, which can slowly precipitate the free acid form, so prepare solutions fresh where possible and keep them closed. Handle the powder in a fume hood or well ventilated area, wear gloves, safety glasses, and a laboratory coat, avoid raising dust, and consult the supplier safety data sheet before use and disposal.
