• 1,1-Diphenylacetone (CAS 781-35-1) - TCI D1397 - AMI Scientific
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TCI

CAS 781-35-1

1,1-Diphenylacetone TCI D1397

1,1-Diphenylacetone TCI D1397
Rp 1.299.900,00
Rp 1.299.900,00
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1,1-Diphenylacetone with CAS number 781-35-1 is a short aliphatic ketone that carries two phenyl rings on the same alpha carbon, producing a branched structure with a doubly benzylic centre adjacent to the carbonyl group. This arrangement makes it a useful non-heterocyclic building block in organic synthesis, particularly when researchers need a framework that combines ketone reactivity with the presence of two aromatic groups within a single molecule. In the laboratory, the compound serves as a starting point for preparing a wide range of derivatives through condensation, alkylation, and reduction reactions, as well as through the construction of heterocyclic rings from its carbonyl framework.

The characteristic that makes this compound attractive is the acidity of the proton on the benzylic carbon flanked by two aromatic rings and a carbonyl group. These electronic conditions stabilise the enolate anion that forms, so deprotonation proceeds more readily than in ordinary aliphatic ketones, and alkylation and condensation reactions can be controlled in a more directed manner. The two phenyl groups also provide useful steric hindrance for guiding the regiochemistry of reactions and for improving the crystallinity of derivative products, which in turn simplifies isolation and purification work at the bench.

In Indonesian laboratories, this building block is typically used in university research groups, organic synthesis teaching laboratories, and research and development units working on the preparation of aromatic ketone derivatives. It is commonly drawn upon when a synthetic route calls for a diaryl-substituted carbonyl skeleton, when reference material is needed for methodology studies, or when a chemistry team is developing new derivatives on a laboratory scale before considering any larger preparation. Supplied under the TCI brand, it fits routine synthetic workflows in academic and industrial research settings.

  • Organic synthesis building block: the diaryl-substituted carbonyl skeleton gives synthetic chemists a ready-made framework for constructing more complex aromatic ketone targets without multi-step assembly of the diphenyl centre.
  • Alkylation and enolate chemistry: the acidic benzylic proton between two phenyl rings and the carbonyl group forms a stabilised enolate, allowing deprotonation and alkylation to be carried out under controlled and directed conditions.
  • Condensation reaction studies: the reactive carbonyl group participates in condensation chemistry, making the compound suitable for preparing extended conjugated systems and substituted derivatives in methodology-focused research work.
  • Heterocyclic ring construction: the carbonyl framework serves as a precursor for building heterocyclic rings, giving researchers access to nitrogen- or oxygen-containing scaffolds derived from a non-heterocyclic starting material.
  • Reduction and derivative preparation: the ketone functionality can be reduced or otherwise transformed, and the two phenyl groups improve the crystallinity of the resulting derivatives, simplifying isolation and purification procedures.

Brand TCI
CAS number 781-35-1
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes —
Physical form —
Storage store in a tightly closed original container, in a cool, dry, well-ventilated area away from light and incompatible materials; pack sizes available on request
  • Product code: D1397
  • Chemical name: 1,1-Diphenylacetone

Store 1,1-Diphenylacetone in its original tightly closed container in a cool, dry and well-ventilated area, protected from direct sunlight, heat sources, open flames and incompatible materials such as strong oxidising agents. Chemically resistant, properly labelled containers with secure closures are recommended, and the container should be reclosed immediately after each use to limit exposure to moisture and air. Handle the compound in a fume hood using standard laboratory personal protective equipment, including safety goggles, gloves and a laboratory coat. Avoid inhalation of dust or vapour and direct contact with skin and eyes, keep the working area clean, and follow institutional waste-handling procedures together with the manufacturer's safety data sheet for detailed guidance.

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