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Description
TCI D2591 2,6-Dimethoxy-4-methylphenol is a substituted phenol carrying two methoxy groups at the positions ortho to the hydroxyl group, together with a single methyl group at the para position. This substitution pattern places it in the syringol family, a structural motif widely recognised as being derived from lignin, the natural polymer that forms part of plant cell walls. In the laboratory it serves both as a building block and as a model compound, helping researchers study the behaviour of lignin fragments, develop new phenolic derivatives, and prepare comparison standards for the analysis of aroma components and biomass degradation products.
The property that makes this compound a frequent choice is the electron richness of its aromatic ring. The hydroxyl group and the two methoxy groups all donate electrons into the ring, which makes it highly reactive towards electrophilic substitution, while the phenolic group forms relatively stable phenoxy radicals with comparative ease. This character is precisely what makes syringol-type compounds attractive for investigations into antioxidant activity and radical-scavenging mechanisms. The hydroxyl group can also be esterified, etherified, or oxidised, giving researchers a wide range of directions for further synthetic development from a single starting material.
In Indonesian laboratories, materials of this type are typically used in university research groups, government research institutes, and industrial R&D units working on natural products, biomass valorisation, and flavour or fragrance chemistry. It is commonly ordered in research-scale quantities for synthetic route development, for use as a reference substance in chromatographic and spectroscopic work, and for teaching and method development in organic chemistry and analytical laboratories where a well-defined lignin-related phenol is required.
Laboratory Applications
- Lignin model compound studies: its syringol-type substitution pattern reproduces a genuine lignin structural motif, allowing degradation and depolymerisation behaviour to be examined on a simple, well-defined molecule.
- Synthesis of phenolic derivatives: the free hydroxyl group can be esterified, etherified, or oxidised, giving a convenient handle for building larger or more functionalised phenolic targets.
- Electrophilic aromatic substitution chemistry: the strongly electron-donating hydroxyl and two methoxy groups activate the ring, so substitution reactions proceed readily under mild laboratory conditions.
- Antioxidant and radical-scavenging research: the phenolic group forms relatively stable phenoxy radicals, which makes this compound useful for probing radical-scavenging mechanisms and structure-activity relationships.
- Analytical reference standard: it serves as a comparison standard when identifying aroma components and biomass degradation products in chromatographic and spectroscopic analyses of complex sample matrices.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 6638-05-7
- Product code: D2591
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Pack sizes: available in standard TCI research-scale packaging; please confirm the currently available pack size when ordering
- Storage: keep in a cool, dry place in a tightly closed container, protected from light and air
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and strong oxidising agents. Because phenolic compounds are susceptible to oxidation and discolouration on exposure to air and light, the original supplier container or an amber glass bottle with a well-sealed cap is the most suitable choice; a nitrogen or argon headspace may be used for material that will be stored over a longer period. Handle the compound in a fume hood, and wear safety goggles, gloves, and a laboratory coat. Avoid inhalation of dust and any contact with skin or eyes, keep the container closed when not in use, and always consult the manufacturer's safety data sheet before handling or disposal.
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