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Description
TCI D2623 Diethylene Glycol Monovinyl Ether is a vinyl ether that carries a diethylene glycol chain with a free hydroxyl group at one end, and it is supplied in a KOH-stabilized state. The molecule combines two characteristics at once: a vinyl ether group that is reactive toward cationic polymerization, and a glycol ether chain that is hydrophilic in nature. In the laboratory, this compound is widely used as a functional monomer, as a reagent for installing protecting groups, and as a building block for drug delivery systems that are sensitive to changes in the acidity of their environment.
The property that makes it a preferred choice is the distinctive reactivity of the vinyl ether group. Vinyl ethers undergo cationic polymerization very readily and can react with alcohols to form acetal linkages — bonds that are stable at neutral pH yet cleave under mildly acidic conditions. It is exactly this behaviour that is exploited to design linkers capable of releasing their payload in an acidic environment. The diethylene glycol chain contributes water solubility, chain flexibility, and biological compatibility, while the terminal hydroxyl group provides an anchoring point for further esterification or conjugation.
Within Indonesian laboratories, the material is typically encountered in pharmaceutical development and drug discovery research groups working on drug delivery systems, as well as in polymer and materials chemistry work. It suits university research laboratories, institutional research centres, and industrial R&D units that prepare functional monomers, acid-labile linkers, and glycol-bearing intermediates on a bench scale, where a reagent supplied already stabilized simplifies day-to-day handling.
Laboratory Applications
Acid-labile linker synthesis: the vinyl ether reacts with alcohols to give acetal bonds that stay intact at neutral pH but cleave in mildly acidic surroundings, which is the core requirement for triggered-release linker chemistry.
pH-responsive drug delivery system construction: the combination of an acid-sensitive acetal-forming group and a hydrophilic, biologically compatible glycol chain makes it a direct building block for carriers designed to release payload in acidic environments.
Cationic polymerization as a functional monomer: vinyl ethers polymerize very readily under cationic conditions, and the pendant diethylene glycol chain introduces hydrophilicity and chain flexibility into the resulting polymer backbone.
Hydroxyl protecting group installation: the vinyl ether functions as a reagent for converting alcohols into acetal-protected derivatives, giving protection that is stable at neutral pH and removable under mild acid treatment.
Conjugation and esterification chemistry: the free terminal hydroxyl group serves as an anchoring point for esterification or further conjugation, allowing the glycol ether unit to be attached to larger molecules or scaffolds.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 929-37-3
Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
Product code: D2623
Pack sizes: available in standard TCI research-scale packaging; please confirm the pack size required when ordering
Condition as supplied: stabilized with KOH
Storage note: keep the container tightly closed and store as indicated on the manufacturer's label; the KOH stabilizer must be retained to preserve the vinyl ether during storage
Handling and Storage
Store the product in its original tightly closed container, kept away from acids, acidic vapours, and any source of moisture, since vinyl ethers are sensitive to acidic conditions and readily undergo cationic polymerization. Keep the KOH stabilizer in place and do not remove it without a clear reason, as it is present to protect the material during storage. Use containers and closures that are chemically compatible with glycol ethers, and reseal them promptly after each withdrawal. Handle the compound in a well-ventilated fume hood while wearing safety glasses, gloves, and a laboratory coat. Follow the manufacturer's Safety Data Sheet for the full list of hazard statements, exposure controls, and waste disposal requirements applicable in your laboratory.
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