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Description
TCI D2651 3,5-Dibenzyloxybenzyl Alcohol is an aromatic compound built around a benzene core carrying two benzyloxy groups at the 3 and 5 positions together with a single benzylic alcohol group at position 1. This three-directional branching architecture is what makes the compound widely recognised as a foundational building block for poly(benzyl ether) dendrons and dendrimers — regularly branched molecules that grow repetitively from one generation to the next. In the laboratory, the material serves as the repeating unit that determines the shape, the size, and the branch density of the final macromolecule a researcher assembles.
The property that leads chemists to select this reagent is the combination of a protecting group and a reactive group within one molecule. The two benzyloxy groups act as phenol protecting groups that remain stable under a broad range of reaction conditions, yet can be removed again through hydrogenolysis whenever the phenolic sites need to be reopened. The benzylic alcohol group, meanwhile, is readily converted into a benzyl halide, a tosylate, or an ether by standard transformations, which makes it the connection point for the next stage of growth.
Its good solubility in common organic solvents, together with its convenient solid form, makes the compound practical to weigh, transfer, and handle on the bench. In Indonesian laboratories it is typically used in university and institutional research groups working on synthetic organic chemistry, polymer and materials chemistry, and supramolecular studies, where dendritic scaffolds are prepared step by step and each generation is characterised before the following coupling stage is carried out.
Laboratory Applications
- Poly(benzyl ether) dendron synthesis — the three-directional substitution pattern supplies exactly one growth point and two protected branch points per repeating unit.
- Convergent and divergent dendrimer construction — the benzylic alcohol is activated to a halide or tosylate, allowing controlled generation-by-generation coupling in either strategy.
- Protecting-group chemistry studies — the two benzyloxy groups demonstrate stable phenol protection that can later be cleaved cleanly by hydrogenolysis when free phenols are required.
- Branched macromolecule and materials research — branch density, molecular size, and overall architecture of the final structure are set by this repeating unit.
- Supramolecular and host–guest scaffold preparation — dendritic frameworks derived from this building block give defined shape and interior space for further functionalisation work.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS Number: 24131-31-5
- Catalogue Code: D2651
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Physical Form: solid, readily handled and soluble in common organic solvents
- Pack Sizes: available in standard TCI research pack sizes; please confirm the currently offered size when ordering
- Storage: keep in a tightly closed container in a cool, dry, well-ventilated place
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, moisture, and strong oxidising agents. Original manufacturer packaging is preferred; if the material is transferred, use clean, dry, chemically compatible and clearly labelled containers, and reseal them immediately after each use to limit moisture uptake. Weigh and transfer the solid in a fume hood or a well-ventilated workspace while wearing safety glasses, gloves, and a laboratory coat. Avoid generating dust, avoid contact with skin and eyes, and wash hands after handling. Keep the container closed during storage, record the opening date, and always consult the manufacturer's Safety Data Sheet before use and before disposal of residues.
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