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Description
TCI D3419 3,4-Diethoxyphenylacetic Acid is a synthetic chemical belonging to the arylacetic acid class, carrying two ethoxy groups at the 3- and 4-positions of the benzene ring. In the laboratory it serves as a protected catechol-type starting framework that already comes equipped with a carboxylic acid group ready to be activated. This diethoxy substitution pattern is a motif that appears repeatedly across a range of bioactive molecules, so having the material available in ready-to-use form saves several etherification and purification steps that are normally time-consuming and that reduce the overall yield of a synthetic sequence.
The property that makes this material a frequent choice is the reliability of its carboxylic acid group as a connection point. That group can be esterified, converted into an acid chloride, or coupled directly with amines using activating reagents to form an amide bond. The adjacent benzylic acetate group also provides conformational flexibility that is useful when designing target molecules. The two ethoxy groups are electron-donating, so they influence the reactivity of the aromatic ring in electrophilic substitution reactions while simultaneously increasing the lipophilicity of the molecule. Its solid physical form makes the material straightforward to weigh out and handle.
In Indonesian laboratories, a building block of this kind is typically used in organic synthesis research groups at universities and in research institutes, as well as in the development work of the pharmaceutical and fine chemical industries. Its solid form supports accurate gravimetric weighing on an analytical balance, which suits multi-step synthesis planning where a single container must serve several reaction batches. Availability from a recognised brand such as TCI also helps laboratories maintain consistency between repeated experiments.
Laboratory Applications
Amide bond formation: the carboxylic acid group can be coupled directly with a wide range of amines using standard activating reagents, making it a convenient acyl donor for building amide-linked target structures.
Ester synthesis: the acid function is readily esterified with alcohols, so the material serves as an acyl component when preparing ester derivatives for further transformation or for property comparison studies.
Acid chloride preparation: conversion of the carboxylic acid into the corresponding acid chloride gives a more reactive intermediate suited to acylation steps that require a stronger electrophile than the free acid.
Multi-step synthesis of bioactive analogues: because the 3,4-diethoxy pattern recurs in bioactive molecules, starting from this pre-substituted framework removes several etherification and purification stages from the route.
Electrophilic aromatic substitution studies: the two electron-donating ethoxy groups activate the aromatic ring, making the compound a useful substrate for examining ring reactivity and substitution behaviour.
Specifications
Brand: TCI
CAS number: 38464-04-9
Product code: D3419
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Physical form: solid
Pack sizes: available in standard laboratory pack sizes; please confirm the packaging option when ordering
Storage: store in a tightly closed container in a cool, dry, well-ventilated place away from light and moisture
Handling and Storage
Keep this material in its original tightly closed container, stored in a cool, dry and well-ventilated area, protected from direct sunlight, moisture and sources of heat or ignition. Glass or other chemically compatible containers with well-sealing caps are suitable, and containers should be clearly labelled and kept closed when not in use to limit moisture uptake by the solid. Handle the compound in a fume hood or a well-ventilated working area, and wear standard laboratory personal protective equipment including safety glasses, gloves and a laboratory coat. Avoid generating and inhaling dust during weighing and transfer, use clean dry spatulas to prevent cross-contamination, and wash hands thoroughly after handling. Separate the material from strong oxidising agents and strong bases, and follow your institution's chemical waste procedures for disposal of residues and contaminated consumables. Always consult the manufacturer's safety data sheet before first use.
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