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TCI

CAS 2941-71-1

2,6-Dimethylbenzothiazole TCI D3674

2,6-Dimethylbenzothiazole TCI D3674
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Description

TCI D3674 2,6-Dimethylbenzothiazole is a heterocyclic building block that combines a benzothiazole core with methyl groups at the 2-position and the 6-position. Benzothiazole is a bicyclic framework containing both nitrogen and sulfur, and it is widely recognized in dye chemistry, medicinal chemistry, the chemistry of vulcanization accelerators, and optical materials. In the laboratory, this compound serves as a starting material for constructing more elaborate benzothiazole derivatives, particularly by exploiting the activated methyl group at the 2-position. The reagent therefore acts as a practical bridge between a simple heterocyclic scaffold and target molecules of high research value.

The characteristic that makes this material a preferred choice is the special reactivity of the methyl group at the 2-position. Because it sits adjacent to the ring nitrogen atom, the hydrogens on that group are comparatively easier to remove, allowing the compound to take part in condensation reactions with aldehydes, the formation of quaternary salts, and the generation of methylene bases that are central to the synthesis of cyanine dyes and fluorescent colorants. The methyl group at the 6-position on the benzene ring contributes a mild electron-donating effect that can shift the electronic character and the overall behaviour of the scaffold, giving researchers a second point of control when tuning a derivative.

In Indonesian laboratories, this building block is typically used in university and institutional research settings where organic synthesis, dye chemistry, and materials work are carried out. It supports method development and derivative preparation on a bench scale, where a well-defined heterocyclic starting material shortens a synthetic route. Because it is supplied as a catalogue reagent from TCI, it fits routine procurement for teaching laboratories, postgraduate research groups, and analytical or formulation development work.

Laboratory Applications

  • Cyanine dye synthesis: the activated 2-methyl group condenses readily to form methylene bases, making this the conventional entry point for building polymethine chromophores in dye chemistry research.
  • Fluorescent colorant preparation: benzothiazole-based fluorophores are built directly from this scaffold, and the reactive 2-methyl position allows straightforward extension of the conjugated system.
  • Heterocyclic derivative construction: as a benzothiazole starting material, it lets synthetic chemists assemble more complex nitrogen- and sulfur-containing targets without preparing the bicyclic core themselves.
  • Quaternary salt formation: the ring nitrogen is available for quaternisation, giving access to salts used as intermediates in dye and functional-material syntheses.
  • Medicinal chemistry exploration: the benzothiazole framework is well established in medicinal chemistry, so this reagent supports the preparation of derivative libraries around a recognised scaffold.

Specifications

  • Brand: TCI (Tokyo Chemical Industry)
  • CAS number: 2941-71-1
  • Chemical name: 2,6-Dimethylbenzothiazole
  • Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
  • Pack sizes: available in standard TCI catalogue research pack sizes; please confirm the size required when ordering
  • Storage: keep in the original closed container under the conditions stated on the manufacturer's label and Safety Data Sheet

Handling and Storage

Store the container tightly closed in a cool, dry, well-ventilated area away from heat, ignition sources, and incompatible materials, following the conditions given on the manufacturer's label and Safety Data Sheet. Keep the reagent in its original supplier container, or in a clean, chemically compatible and clearly labelled vessel if transferred. Handle in a fume hood using safety glasses, gloves, and a laboratory coat, and avoid inhaling vapour or generating dust. Close the container immediately after dispensing, keep records of opening dates, and collect residues and contaminated materials as chemical waste for disposal according to institutional procedures.

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