TCI
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Description
2,4-Dimethyloxazole is a five-membered heterocyclic compound containing one nitrogen atom and one oxygen atom in its ring, with methyl groups attached at the 2- and 4-positions. As a heterocyclic building block, it supplies organic synthesis researchers with a ready-to-use oxazole core. The oxazole nucleus itself is a motif frequently encountered in bioactive compounds, aroma materials, and ligands, yet assembling it from simple starting materials normally demands dedicated cyclization reactions. Having the ring available in a prepared form therefore removes several preparatory steps from the laboratory workflow.
The property that makes this compound a preferred choice is the versatile reactivity of the oxazole ring. The ring nitrogen atom is weakly basic and is capable of coordinating to metal ions, while the oxazole ring is well known for its ability to act as a diene in Diels–Alder cycloaddition reactions with suitable dienophiles — a classical route toward substituted pyridine rings. The two methyl groups on the ring also provide positions that can be further functionalized through deprotonation or radical reactions, giving synthetic chemists more than one handle on a single small molecule.
In Indonesian laboratories, this material is typically used in university research groups, government research institutes, and industrial R&D units engaged in organic synthesis and heterocyclic chemistry. Because it is a low molecular weight compound that tends to be volatile, it is supplied in sealed packaging and is normally handled in bench-scale synthesis, method development, and reference preparation work where a defined heterocyclic starting material is required rather than one prepared in-house.
Laboratory Applications
- Heterocyclic synthesis — the prepared oxazole core allows researchers to begin work directly from a defined ring system instead of running a dedicated cyclization step from simple precursors.
- Diels–Alder cycloaddition studies — the oxazole ring can act as a diene toward suitable dienophiles, giving a classical synthetic route toward substituted pyridine ring systems.
- Ligand and coordination chemistry work — the weakly basic ring nitrogen atom is able to coordinate to metal ions, making the compound useful in preparing nitrogen-donor ligand structures.
- Building block for bioactive compound research — the oxazole motif is frequently found in bioactive molecules, so this material serves as an entry point in medicinal chemistry exploration.
- Functionalization and derivatization studies — the two ring methyl groups offer positions that can be modified further through deprotonation or radical reactions to build more elaborate targets.
Specifications
- Brand: TCI
- Product code: D3766
- CAS number: 7208-05-1
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Physical form: low molecular weight organic compound with a tendency to be volatile
- Storage: keep in the sealed original packaging; refer to the manufacturer's label and safety data sheet for the specified storage condition
Handling and Storage
Store the compound in its tightly closed original container, kept sealed at all times because this low molecular weight material tends to be volatile and can be lost through an inadequately closed cap. Suitable containers are chemically compatible glass bottles with tight-sealing closures, kept upright in a well-ventilated chemical store away from ignition sources, oxidizing agents, and direct sunlight. Handle transfers and reaction setup inside a fume hood, wearing safety glasses, gloves, and a laboratory coat. Allow refrigerated material to reach room temperature before opening to avoid moisture condensation, and always consult the manufacturer's safety data sheet for the specific storage temperature and disposal requirements before use.
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