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Description
TCI D3996 Dantrolene Sodium Salt Hydrate (CAS 14663-23-1) is the hydrated sodium salt form of dantrolene, a hydantoin-derived compound widely recognised in the study of muscle physiology and intracellular calcium signalling. In the laboratory it serves as a pharmaceutical research reagent intended for experimental use only: researchers employ it to examine calcium release from the sarcoplasmic reticulum, particularly release mediated by the ryanodine receptor. Its presence in an assay system helps clarify the mechanisms of muscle contraction, disturbances of calcium homeostasis, and the cellular pathways associated with calcium stress.
The properties that make this material a preferred reagent begin with its relatively specific action on the calcium release pathway, which allows investigators to probe that route without broadly perturbing unrelated cellular processes. Equally important is the sodium salt form, which is considerably easier to dissolve than the neutral base form of the compound. Improved solubility in aqueous media and in mixtures with dimethyl sulfoxide is a genuine practical advantage when preparing stock solutions for cell culture assays, isolated tissue experiments, and calcium fluorescence measurements. The water of crystallisation present in the hydrate form contributes solid-state stability under ordinary storage conditions, which supports consistent handling across a series of experiments.
In Indonesian laboratories, this reagent is typically encountered in university and institutional research settings where muscle physiology, calcium signalling, and pharmacological mechanisms are investigated. It is generally used at the bench for preparing stock solutions that feed into cell culture work, isolated tissue preparations, and fluorescence-based calcium measurements. Because it is supplied as a pharmaceutical research reagent for experimental purposes, it belongs in research and teaching laboratories rather than in any clinical or therapeutic workflow.
Laboratory Applications
Sarcoplasmic reticulum calcium release studies — the compound acts on the release pathway from the sarcoplasmic reticulum, making it a direct experimental tool for probing how stored calcium is mobilised.
Ryanodine receptor research — because its action is mediated through the ryanodine receptor, it allows investigators to interrogate that specific channel in mechanistic studies of calcium handling.
Muscle contraction mechanism investigations — its established role in muscle physiology research makes it suitable for experiments designed to explain how contraction is initiated and regulated at the cellular level.
Calcium homeostasis and calcium stress pathway work — researchers use it to examine disturbances of intracellular calcium balance and the cellular pathways that respond to calcium stress conditions.
Cell culture assays and calcium fluorescence measurements — the soluble sodium salt form dissolves readily enough in aqueous media and DMSO mixtures to prepare stock solutions for fluorescence-based calcium detection.
Specifications
Brand: TCI
Product code: D3996
CAS number: 14663-23-1
Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Physical form: solid, supplied as the hydrated sodium salt
Pack sizes: available in TCI catalogue pack sizes; please confirm the size required when ordering
Storage note: store in a closed container and protect solutions from light
Handling and Storage
Store the solid in its original tightly closed container under ordinary storage conditions; the water of crystallisation in the hydrate form supports solid-state stability during normal storage. Because this is a chromophore-bearing compound, solutions should be protected from light to preserve their quality — amber glass vials or containers wrapped in foil are appropriate for prepared stock solutions. Handle the material in a well-ventilated area using standard personal protective equipment, including gloves, safety glasses, and a laboratory coat. Prepare stock solutions in aqueous media or DMSO mixtures immediately before use where practical, keep containers closed when not in use, and follow your institution's general laboratory practice for chemical handling. This product is intended for experimental research use only and is not for clinical, diagnostic, or therapeutic application.
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