2,5-Difluorobenzenesulfonamide TCI D4060

Name: TCI D4060 120022-63-1 2,5-Difluorobenzenesulfonamide
Brand: TCI
SKU: TCI2510D406024540
Price: 739200.0 IDR
Availability: InStock

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Berat 1g 5g

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Description

TCI D4060 2,5-Difluorobenzenesulfonamide is a fluorinated building block that brings together two elements of central importance in medicinal chemistry: a primary sulfonamide group and two fluorine atoms on the benzene ring. In the laboratory, this compound serves as a starting material that already carries a ready-to-use sulfonamide pharmacophore, allowing researchers to direct their effort immediately toward modification of the aromatic ring or derivatisation of the sulfonamide nitrogen. This kind of role is particularly valuable when assembling libraries of test compounds, because it shortens the synthetic route and reduces the number of purification steps that have to be carried out.

The characteristics that make this material attractive lie in the combination of its functional groups. The primary sulfonamide acts as both a hydrogen bond donor and acceptor, and is therefore widely recognised as a binding motif for a range of biological targets, particularly enzymes that contain a metal centre at the active site. The two fluorine atoms at the 2- and 5-positions, meanwhile, withdraw electron density from the ring, influencing the acidity of the sulfonamide group, improving metabolic stability, and providing positions that can be displaced through nucleophilic aromatic substitution. This flexibility is what allows a single starting material to be developed along several different synthetic directions.

In Indonesian laboratories, a building block of this type is generally used in university research groups, pharmaceutical research and development units, and contract synthesis laboratories working on the preparation of new candidate molecules. It is typically handled in organic synthesis work at the milligram to gram scale, followed by characterisation using standard instrumentation. Because the compound is supplied as a defined reagent identified by its CAS number, ordering and documentation for research projects and internal quality records remain straightforward.

Laboratory Applications

Medicinal chemistry synthesis: the primary sulfonamide is a well-established binding motif, so the compound provides a pharmacophore-bearing starting point without the need for an additional installation step.
Compound library preparation: a single scaffold can be diversified through several routes, shortening the synthetic sequence and reducing the number of purification stages needed for each analogue.
Nucleophilic aromatic substitution studies: the two ring fluorines are activated by the electron-withdrawing sulfonamide group and can be displaced to introduce a range of new substituents.
Sulfonamide nitrogen derivatisation: the free NH2 of the sulfonamide offers a direct handle for alkylation, acylation, or other transformations that extend the molecule in a controlled way.
Structure-activity relationship investigations: fluorine substitution modulates sulfonamide acidity and metabolic stability, making this material useful for probing how such changes affect target interaction.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 120022-63-1
Chemical name: 2,5-Difluorobenzenesulfonamide
Product code: D4060
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes: available in standard TCI research quantities; please refer to the current catalogue listing for the packaging options offered
Storage: keep in the tightly closed original container, in a cool, dry, well-ventilated place away from light and moisture

Handling and Storage

Store the material in its original tightly closed container in a cool, dry, and well-ventilated area, protected from direct sunlight, moisture, and sources of ignition or heat. Glass bottles with chemically resistant closures are suitable for storage and for transferring smaller working portions. Handle the compound in a fume hood, using gloves, safety glasses, and a laboratory coat, and avoid the generation and inhalation of dust during weighing. Reseal the container promptly after use so that the contents do not take up atmospheric moisture, label all working solutions clearly, and keep the compound separate from strong oxidising agents and strong bases. Always consult the manufacturer's safety data sheet before first use, and dispose of residues and contaminated materials through the laboratory's chemical waste procedure.