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TCI

CAS 77883-43-3

Doxazosin Mesylate TCI D4126

Doxazosin Mesylate TCI D4126
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Description

TCI D4126 Doxazosin Mesylate is a pharmaceutical research reagent supplied as the mesylate salt of doxazosin, a quinazoline-class compound widely recognised as an α1-adrenergic receptor antagonist. In the laboratory it serves as a reference and test compound for receptor pharmacology research, structure–activity relationship studies, and the development and validation of analytical methods. The product is intended strictly for experimental and research purposes and is not for diagnostic, therapeutic, or human consumption use, so it should be handled within a clearly defined research protocol that is properly documented by the responsible investigator.

The mesylate salt form is chosen for many pharmaceutical reagents because it generally offers more practical handling than the corresponding free base, particularly in terms of ease of weighing and dissolution in the solvent systems commonly used for in vitro assays. As a solid, the compound can be measured accurately at the milligram scale, making it well suited to the preparation of stock solutions at defined concentrations that are subsequently diluted in a stepwise series. Its quinazoline character, with a benzodioxane group in the structure, also makes it a recognisable subject for structural and analytical study.

In Indonesian laboratories, this reagent fits naturally into university research groups, pharmacy and pharmacology faculties, and analytical laboratories that require a well-defined comparison compound. It is typically ordered for receptor-focused experimental work, for method development supporting analytical instrumentation, and for structure–activity investigations where a consistent, clearly identified reference material is needed across repeated experimental runs and across different members of a research team.

Laboratory Applications

  • Receptor pharmacology studies — as a known α1-adrenergic receptor antagonist, it provides a defined reference point for characterising receptor response behaviour in controlled experimental systems.
  • Structure–activity relationship research — its quinazoline scaffold bearing a benzodioxane group makes it a useful structural reference when comparing related compounds and interpreting activity trends.
  • Analytical method development — the material serves as a test compound when establishing separation, detection, and quantification procedures before a method is applied more broadly.
  • Analytical method validation — as a consistently identified reference substance, it supports validation work where reproducible identity and defined handling are required across repeated runs.
  • Preparation of stock and serial dilution series — the solid form allows accurate milligram-scale weighing for stock solutions that are then diluted stepwise for in vitro testing.

Specifications

  • Brand: TCI
  • CAS Number: 77883-43-3
  • Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
  • Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering
  • Physical form: solid, suitable for milligram-scale weighing
  • Storage: store according to the manufacturer's instructions on the product label and safety data sheet

Handling and Storage

Store the reagent in its original tightly closed container, kept in a cool, dry, well-ventilated place away from direct sunlight, moisture, and incompatible materials, following the conditions stated by the manufacturer on the label and safety data sheet. Use clean, dry, chemically compatible containers such as glass vials with sealed closures for any prepared stock solutions, and label them clearly with the compound name, concentration, and preparation date. Handle the solid in a fume hood or well-ventilated area, wearing a laboratory coat, gloves, and eye protection, and avoid generating dust during weighing. Because this material is for experimental use only, restrict access to trained personnel, record all handling within the applicable research protocol, and dispose of residues and contaminated consumables through the laboratory's established chemical waste procedures.

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