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Description
TCI D4227 Dexrazoxane is a bisdioxopiperazine compound widely recognized as a strong chelating agent, particularly toward metal ions such as iron. In biological systems as well as in solution, this compound can hydrolyse into an open form that resembles the structure of EDTA, allowing it to bind metal ions effectively. Within the synthetic reagents category, this material is used as a chelating and complex-forming compound for studying the role of metal ions in chemical reactions and biological processes, and as a comparison compound in research related to metal-mediated oxidative stress.
The characteristic that makes this compound a preferred choice is its ability to act as a prochelator: the relatively neutral cyclic form can penetrate certain environments and then hydrolyse into the active chelator, so that metal ion binding occurs in a more targeted manner compared with adding a free chelator from the outset. In addition, dexrazoxane is also known as a compound that interacts with topoisomerase II, making it a useful research tool in studies of DNA damage mechanisms and cell protection. The combination of these two properties is what makes it frequently adopted as a reference compound.
In Indonesian laboratories, this material is typically used in academic and institutional research settings where metal ion chemistry and complexation behaviour are examined under controlled conditions. It suits synthetic chemistry work benches, biochemical study groups, and oxidative stress research programmes that require a well-characterised chelating compound. Researchers generally handle it in small working quantities as part of comparative studies, using it alongside other chelating agents so that results can be interpreted against an established reference material.
Laboratory Applications
Metal ion chelation studies: the compound binds metal ions such as iron effectively after hydrolysis into its open EDTA-like form, making it suitable for controlled binding experiments.
Complexation chemistry research: as a complex-forming compound, it allows researchers to examine how metal ions influence reaction pathways and product formation in synthetic systems.
Metal-mediated oxidative stress investigations: it serves as a comparison compound in studies where iron and other metal ions contribute to oxidative processes in biological or model systems.
Prochelator mechanism work: the relatively neutral cyclic form penetrates certain environments before hydrolysing to the active chelator, enabling more targeted metal binding than free chelators.
Topoisomerase II interaction research: its known interaction with topoisomerase II makes it a useful tool compound in studies of DNA damage mechanisms and cell protection.
Pack sizes: available in standard TCI research pack sizes; please confirm the currently offered pack size when ordering
Storage: store according to the manufacturer's labelling on the container and accompanying documentation
Handling and Storage
Store the container in a cool, dry, well-ventilated place, tightly closed and protected from moisture and direct sunlight, following the storage conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original container, or in a clean, chemically compatible and clearly labelled vessel if transferred. Handle in a fume hood or well-ventilated area using standard personal protective equipment, including a laboratory coat, safety glasses, and suitable gloves. Avoid inhaling dust and avoid contact with skin and eyes. Use clean, dry spatulas when weighing to prevent contamination, close the container promptly after use, and dispose of residues and contaminated materials in accordance with applicable laboratory waste procedures.
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