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Description
TCI D4762 4-(Difluoromethoxy)benzoic Acid is a benzoic acid derivative carrying a difluoromethoxy group at the para position. The compound is classified as a fluorinated building block — a starting material that already bears its fluorine motif, allowing researchers to use it directly without running a separate fluorination step. Its carboxylic acid group is one of the most readily manipulated functional groups in organic chemistry: it can be activated to an acid chloride, ester, amide, or anhydride, and it also serves as an attachment point in coupling reactions that assemble larger molecular frameworks.
The characteristics that make this material a frequent choice are its stability and practicality. As an aromatic carboxylic acid solid, it is generally straightforward to weigh out, to store, and to repurify by recrystallisation when required. The difluoromethoxy group is inductively electron-withdrawing, so it influences the acidity of the compound and the reactivity of the aromatic ring, while in drug design this same group is recognised for its role in tuning lipophilicity and resistance to metabolism. The combination of a versatile functional group with a design-relevant fluorine motif is what gives the compound its broad appeal.
In Indonesian laboratories, this material fits naturally into synthetic and medicinal chemistry work at universities, research institutes, and industrial R&D groups. It is typically drawn on where a para-substituted fluorinated aromatic acid is needed as an intermediate, as a coupling partner, or as a reference material in method development. Because it arrives with the fluorine motif already in place, groups without dedicated fluorination capability can still access fluorinated scaffolds using standard bench equipment.
Laboratory Applications
- Amide bond formation — the carboxylic acid group can be activated and coupled with amines, making this a direct route to fluorinated benzamide structures without a separate fluorination step.
- Esterification and ester library work — the acid converts readily to esters, letting chemists prepare series of derivatives from a single well-defined fluorinated starting material.
- Acid chloride and anhydride preparation — activation to the acid chloride or anhydride gives a more reactive acylating agent for onward transformations in multi-step synthesis.
- Medicinal chemistry scaffold construction — the difluoromethoxy motif is used to tune lipophilicity and metabolic resistance, so this acid serves as a building block in structure–activity studies.
- Coupling reactions toward larger frameworks — the carboxylic acid functions as an attachment point when assembling more elaborate molecular architectures around a fluorinated aromatic core.
Specifications
- Brand: TCI
- CAS number: 4837-20-1
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in the pack sizes listed on this product page
- Physical form: solid aromatic carboxylic acid
- Storage: keep tightly closed in its original container, protected from moisture
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, well-ventilated area, away from moisture and incompatible substances such as strong bases and strong oxidising agents. Glass containers with chemically resistant closures are suitable for transfers and for the preparation of stock solutions. Handle in a fume hood and wear safety glasses, gloves, and a laboratory coat, since aromatic carboxylic acids can irritate skin, eyes, and the respiratory tract. Avoid generating dust when weighing, close the container promptly after use to limit moisture uptake, and consult the manufacturer's safety data sheet before use. Dispose of residues and contaminated materials through your institution's chemical waste procedures.
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