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Description
TCI D4334, 4-(Difluoromethoxy)benzaldehyde, is a fluorinated building block that combines two important structural features in a single molecule: an aromatic aldehyde group and a difluoromethoxy group at the para position. In the laboratory, this compound serves as a starting material for introducing the OCHF₂ motif into target molecules while simultaneously providing a highly versatile aldehyde handle. The aldehyde group can be elaborated through reduction, oxidation, reductive amination, condensation, and the many carbon–carbon bond-forming reactions that form the backbone of everyday organic synthesis.
The reason this compound is so frequently chosen lies in the distinctive character of the difluoromethoxy group. This fragment is electron-withdrawing while also able to act as a weak hydrogen-bond donor through its hydrogen atom, a combination rarely found in other substituents. In medicinal chemistry and agrochemical research, the motif is often used to improve metabolic stability, tune lipophilicity, and modulate the acidity or basicity of neighbouring groups. The presence of fluorine atoms also offers an analytical advantage, since the molecule can be monitored spectroscopically.
In Indonesian laboratories, this material is typically used in university research groups, pharmaceutical and agrochemical development units, and contract synthesis facilities that build fluorinated analogues of lead compounds. It is generally handled at small to moderate scale on the bench, where the aldehyde functionality is converted in one or two steps into the desired intermediate. Because it arrives as a defined catalogue item from TCI, it fits well into workflows where a reproducible, well-characterised starting material is required for repeated synthetic campaigns.
Laboratory Applications
- Introduction of the OCHF₂ motif into target molecules, allowing chemists to install a fluorinated substituent that is otherwise difficult to append directly onto an existing aromatic scaffold.
- Reductive amination chemistry, where the aromatic aldehyde reacts with primary or secondary amines to build benzylamine derivatives that carry the difluoromethoxy group intact.
- Condensation reactions such as imine, hydrazone, and related formations, taking advantage of the reactive aldehyde while the para substituent tunes the electronic character of the ring.
- Carbon–carbon bond-forming steps that use the aldehyde as an electrophilic partner, providing access to extended fluorinated frameworks from a single readily handled starting material.
- Medicinal chemistry and agrochemical analogue synthesis, where the difluoromethoxy group is deliberately incorporated to improve metabolic stability and adjust lipophilicity in candidate structures.
Specifications
- Brand: TCI (Tokyo Chemical Industry), catalogue code D4334
- CAS Number: 73960-07-3
- Chemical name: 4-(Difluoromethoxy)benzaldehyde
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard TCI research-scale catalogue packs; please confirm the size required when ordering
- Storage: keep in the tightly closed original container in a cool, dry, well-ventilated place, following the storage note on the supplied label
Handling and Storage
Store the material in its tightly closed original container in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidising agents, strong bases, and amines. Aromatic aldehydes are generally sensitive to air and moisture, so the container should be closed promptly after each use and, where the intended chemistry demands it, handled under an inert atmosphere. Weighing and transfer should be carried out in a fume hood using appropriate personal protective equipment, including safety glasses, chemical-resistant gloves, and a laboratory coat. Avoid inhalation of vapours and contact with skin and eyes, and always consult the manufacturer's Safety Data Sheet before beginning work. Dispose of residues and contaminated materials in accordance with the applicable chemical waste procedures of your institution.
