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CAS 7338-94-5

1,3-Diphenylprop-2-yn-1-one TCI D6145

1,3-Diphenylprop-2-yn-1-one TCI D6145
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Description

1,3-Diphenylprop-2-yn-1-one, also known as diphenylpropynone, is an organic compound belonging to the class of conjugated alkynes and serves as an important building block in organic synthesis. The compound contains a ketone carbonyl group conjugated with a carbon-carbon triple bond, giving it distinctive reactivity that allows it to be converted into more complex molecular frameworks. In the organic chemistry laboratory, it is frequently used as a starting substrate or intermediate reagent in the preparation of heterocyclic compounds, chalcone derivatives, and carbon-framed molecules required for pharmaceutical research, fine chemicals, and functional materials.

The main advantage of this compound lies in the combination of mutually supportive functional groups: an electrophilic carbonyl group, two phenyl rings that provide stability and lipophilic character, and a triple bond that is highly reactive toward various transition metal catalysts. This structure makes it an ideal substrate for cycloaddition reactions, nucleophilic additions, and metal-catalyzed reactions involving gold, palladium, or copper. Because its reactivity profile is well defined and predictable, researchers can obtain consistent, reproducible results, making this reagent a preferred choice for method development and for constructing diverse carbon skeletons in a single synthetic operation.

In Indonesian laboratories, particularly in academic research institutions, pharmaceutical development facilities, and fine chemical industries, 1,3-diphenylprop-2-yn-1-one is commonly employed as a dependable building block for advanced organic synthesis coursework and for research projects exploring new catalytic transformations and heterocyclic scaffolds. It is also used in the preparation of chalcone-related compounds, which are of ongoing interest in local medicinal chemistry studies. As a catalogued TCI reagent supplied by AMI Scientific, it fits readily into standard laboratory workflows, supporting both undergraduate practical classes and postgraduate research programs across the country.

Laboratory Applications

  • Synthesis of heterocyclic compounds: its conjugated alkyne-carbonyl system readily participates in cycloaddition and cyclization pathways, enabling the controlled construction of diverse heterocyclic ring systems from a single well-defined substrate.
  • Preparation of chalcone derivatives: the enone-like reactivity of the carbonyl and alkyne units allows straightforward derivatization, making this compound a convenient precursor for chalcone-type structures widely examined in medicinal chemistry research.
  • Transition metal-catalyzed reactions: the carbon-carbon triple bond is highly reactive toward gold, palladium, and copper catalysts, making this substrate especially well suited to studies of novel catalytic transformations and mechanistic investigations.
  • Nucleophilic addition studies: the electrophilic carbonyl group accepts a broad range of nucleophiles, providing a versatile platform for exploring addition pathways and for building functionalized carbon frameworks in a controlled manner.
  • Building blocks for functional materials and fine chemicals: its rigid conjugated backbone and lipophilic phenyl rings are valuable for assembling extended pi-systems and structurally defined molecules needed for materials-oriented research and specialty chemical development.

Specifications

  • Brand: TCI
  • Product name: TCI D6145 7338-94-5 1,3-Diphenylprop-2-yn-1-one
  • CAS number: 7338-94-5
  • Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
  • Physical form: not indicated in the source data; supplied as a laboratory-grade chemical reagent
  • Storage note: keep in a cool, dry place, protected from light, moisture, and sources of heat

Handling and Storage

This compound should be stored in its original, tightly sealed container in a cool, dry, well-ventilated area, protected from direct sunlight and sources of heat. Keep the container closed when not in use to prevent moisture absorption and contamination. Use clean, suitable laboratory glassware and transfer tools, and avoid contact with incompatible substances. When handling, wear appropriate personal protective equipment such as laboratory gloves and safety goggles, and work in a fume hood or well-ventilated area. Avoid inhalation of dust, do not eat or drink in the work area, and wash hands thoroughly after handling. Keep the material away from open flames and strong oxidizing agents, and follow standard chemical hygiene practices in line with your laboratory's safety procedures.

*(Asumsi: informasi teknis seperti bentuk fisik dan ukuran kemasan tidak tersedia pada data sumber, sehingga tidak dicantumkan angka spesifik.)*

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