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Description
TCI E0159 4-Ethylphenol is a substituted phenol carrying an ethyl group at the para position relative to the hydroxyl group. It belongs to the class of non-heterocyclic building blocks and is widely used both as a starting material for synthesis and as a reference compound in analytical work. In the laboratory, alkylphenols of this type matter because the phenolic hydroxyl group can be etherified, esterified, or oxidised, while the aromatic ring still retains open positions available for substitution reactions. Beyond synthesis, 4-ethylphenol is widely recognised as an aroma marker compound in fermented products, which makes it a frequent requirement in food and beverage chemistry studies.
The characteristics that lead researchers to select this compound are the weak acidity of the phenolic group, which allows phenoxide formation to be carried out in a controlled manner, and the electron-donating nature of the ethyl group, which directs substitution reactions toward particular positions on the ring. Taken together, this combination gives researchers good control over the direction of a reaction. The ethyl group also raises lipophilicity compared with simple phenol, so the compound is useful in structure–property relationship studies, including work on solubility, distribution behaviour, and retention behaviour in chromatography.
In Indonesian laboratories, TCI E0159 4-Ethylphenol is typically used in academic and institutional research settings where organic synthesis, analytical method development, and food and beverage chemistry are routine activities. Because it serves as both a synthetic intermediate and an analytical reference standard, it is commonly requested by university chemistry departments, research institutes, and quality control laboratories that handle fermented product analysis or that prepare substituted phenol derivatives as part of ongoing method and materials work.
Laboratory Applications
- Organic synthesis starting material: the phenolic hydroxyl group can be etherified, esterified, or oxidised, giving chemists several independent routes for building more complex substituted phenol derivatives.
- Aromatic substitution chemistry: the electron-donating ethyl group directs incoming substituents to specific ring positions, so open positions on the aromatic ring can be functionalised with predictable regiochemistry.
- Analytical reference compound: 4-ethylphenol is used as a reference substance in analytical work, supporting peak identification and method calibration where a well-defined alkylphenol standard is required.
- Food and beverage chemistry studies: the compound is widely recognised as an aroma marker in fermented products, making it necessary for laboratories investigating flavour and off-flavour formation.
- Structure–property relationship studies: increased lipophilicity relative to simple phenol makes this material useful for examining solubility, distribution, and chromatographic retention behaviour across a homologous series.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 123-07-9
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Catalogue number: E0159
- Pack sizes: available in standard TCI research and laboratory pack sizes; please confirm the required size when ordering
- Storage: keep in a closed original container under the conditions stated on the manufacturer label and accompanying documentation
Handling and Storage
Store TCI E0159 4-Ethylphenol in its tightly closed original container, in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible chemicals such as strong oxidising agents. Chemically resistant amber glass containers are suitable for aliquots, and containers should be clearly labelled with the compound name and CAS number. As with other phenolic compounds, handle the material inside a fume hood and wear appropriate personal protective equipment, including chemical-resistant gloves, safety goggles, and a laboratory coat, since phenols can irritate skin, eyes, and the respiratory tract. Avoid generating dust or vapour, keep the container closed when not in use, and consult the manufacturer safety data sheet before first use and before waste disposal.
