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Description
TCI E0160 2-Ethylphenol is the ortho isomer of ethylphenol, a phenolic compound in which the ethyl group is attached to the carbon immediately adjacent to the hydroxyl group. The material is classified as a non-heterocyclic building block and is supplied as a liquid. In laboratory work it serves as a starting material for the synthesis of phenolic derivatives, as a model substrate for studying how steric hindrance affects the reactivity of the hydroxyl group, and as a comparison compound in phenol-group analyses that require clear separation between isomers.
The distinguishing feature of the ortho isomer lies in the proximity of the ethyl group to the hydroxyl group. This closeness creates steric hindrance that reduces the readiness of the hydroxyl group to react with bulky reagents, while at the same time permitting intramolecular interactions that influence acidity, boiling behaviour, and spectroscopic absorption patterns. These subtle differences are precisely why the compound is so often used in pairs with the meta and para isomers in structure–property relationship studies, where the isomer set as a whole carries more information than any single member of it.
Its liquid form makes pipette measurement and stock solution preparation straightforward, but it also means the material spreads easily if spilled and releases a characteristic phenolic odour into the working area. Indonesian laboratories therefore tend to handle it in a fume hood on a contained bench surface, dispensing it into tared vials or volumetric flasks and returning the bottle promptly to storage — a practical routine in organic synthesis groups, analytical method development, and university teaching laboratories alike.
Laboratory Applications
Synthesis of phenolic derivatives: the free hydroxyl group and the activated aromatic ring make this compound a convenient starting point for building more elaborate phenolic structures.
Steric hindrance studies: because the ethyl group sits directly beside the hydroxyl group, reactions with bulky reagents proceed differently here, making the compound an informative model substrate.
Isomer separation reference in chromatography: analysts use it as a comparison compound when a phenol-group method must demonstrate clear resolution between ortho, meta, and para isomers.
Structure–property relationship investigations: paired with the meta and para isomers, it reveals how substituent position shifts acidity, boiling point, and spectroscopic response within one compound family.
Spectroscopic reference and teaching material: the intramolecular interaction produced by the ortho arrangement gives characteristic absorption patterns useful for instrument calibration checks and student interpretation exercises.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 90-00-6
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Physical form: liquid
Pack sizes: available in standard TCI research and laboratory packaging; please confirm the size options when ordering
Storage note: keep in a tightly closed original container in a cool, dark, well-ventilated chemical store
Handling and Storage
Store the bottle tightly closed in a cool, dark, well-ventilated chemical cabinet, kept upright and away from heat sources, direct sunlight, and strong oxidising agents. The original manufacturer container is the most suitable vessel; where transfer is necessary, use glass with a chemically compatible closure rather than ordinary plastic. Because the material is a liquid with a noticeable phenolic odour, dispense it inside a fume hood while wearing safety glasses, gloves, and a laboratory coat. Work over a contained surface so that spills stay local, absorb any spillage promptly, and avoid skin contact and inhalation of vapour. Wash hands after handling and return the container to its designated storage location immediately after use.
