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Description
TCI E0796 N-Ethyl-p-menthane-3-carboxamide, CAS 39711-79-0, is a carboxamide compound derived from the p-menthane skeleton — the same terpenoid framework that underlies menthol. It is widely recognised among researchers as a physiological cooling agent: a substance that produces a sensation of coolness on skin and mucous membranes without actually lowering temperature. In the laboratory, this material serves as a sensory research reagent, an analytical reference substance, and a pharmacological tool for studying temperature-sensing pathways in cells and tissues.
The characteristic that sets this compound apart is the separation between its cooling effect and its aroma. Unlike menthol, which carries a strong mint odour, this carboxamide delivers a long-lasting cooling sensation with a very weak scent, allowing researchers to examine cooling effects independently of olfactory influence. Mechanistically, it acts as an agonist of the cold-sensing ion channels of sensory nerves, specifically the TRPM8 channel — the same receptor activated by low temperatures. Its solid, stable physical form also makes accurate weighing and stock solution preparation straightforward.
In Indonesian laboratories, this material is typically handled in academic research groups, sensory science units, and formulation development laboratories that require a well-characterised reference compound rather than an unspecified technical-grade material. Because it is supplied as a stable solid in defined pack sizes, it fits work programmes where the same reagent must be weighed out repeatedly over an extended study period while keeping results comparable between batches and between analysts.
Laboratory Applications
- Sensory research studies — provides a controlled cooling stimulus with very weak aroma, so panel and cell-based responses can be attributed to cooling rather than odour.
- TRPM8 receptor pharmacology — acts as an agonist of the cold-sensing ion channel, making it a practical tool compound for probing thermosensation pathways in sensory nerve preparations.
- Analytical reference material — its defined identity under CAS 39711-79-0 supports use as a comparison standard when identifying or confirming cooling agents in analytical workflows.
- Formulation development screening — the long-lasting cooling sensation without strong mint character allows developers to evaluate cooling performance separately from any fragrance system used.
- Cell and tissue temperature-sensing assays — the stable solid form permits accurate weighing and reproducible stock solution preparation for dose-dependent work on cultured cells and tissue.
Specifications
- Brand: TCI
- CAS number: 39711-79-0
- Category: Life Science > Biochemicals and Reagents > Terpenes
- Pack sizes: available in the catalogue pack sizes offered for this item
- Physical form: solid
- Storage: keep in a closed original container under the conditions stated on the product label
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible chemicals. Keep the material in its original supplier container or in a clean, chemically resistant, clearly labelled vessel, and reseal it promptly after each weighing to limit moisture uptake and contamination. Handle the solid in a fume hood or a well-ventilated workspace, using a laboratory coat, safety glasses, and suitable gloves. Avoid generating dust, and avoid contact with skin, eyes, and mucous membranes. Weigh out only the quantity required, return the remainder to storage without delay, and follow the supplier safety data sheet together with local institutional waste-disposal procedures.
