TCI E0838 Ethyl trans-4-Hydroxycyclohexanecarboxylate is the ethyl ester of cyclohexanecarboxylic acid bearing a hydroxyl group at the four position in a trans orientation. The material is a bifunctional non-heterocyclic building block with defined geometry, which makes it highly valued in targeted molecular synthesis. In the laboratory, its role is to supply a rigid cyclohexane framework carrying two opposing functional groups at either end of the ring, namely an ester group and an alcohol group. This arrangement is very useful for constructing molecular linkers, installing spacer groups on drug candidate compounds, and introducing a measured distance between functional groups.
The principal value of this material lies in its stereochemistry. The trans configuration places the hydroxyl and ester groups in positions that point away from one another, generally with both in an equatorial orientation in the most favoured ring conformation, so that the molecule becomes relatively extended and predictable in shape. This property matters to medicinal chemistry, because a controlled molecular shape determines how well a compound fits the binding pocket of a biological target. In addition, the two functional groups can be worked on separately, allowing chemists to modify one end of the ring while leaving the other end intact for a later step.
In Indonesian laboratories, this building block is typically used in university and institutional synthetic chemistry groups, in pharmaceutical research units developing new candidate structures, and in analytical or method-development work that requires a well-defined reference scaffold. It is normally purchased in research quantities for bench-scale reactions rather than for production use, and it is handled with the same care given to other TCI fine chemicals held in a research chemical store.
- Molecular linker construction: the rigid trans-disubstituted cyclohexane ring provides a fixed, predictable distance between two attachment points, making it a reliable spacer element in linker design work.
- Medicinal chemistry scaffold synthesis: the defined trans geometry gives conformational control that helps chemists match a candidate compound to the shape of a biological target binding pocket.
- Selective functional group transformation: the ester and the alcohol can be addressed independently, so one terminus may be modified while the other is preserved for a subsequent synthetic step.
- Spacer group installation on drug candidates: the bifunctional ring can be appended to an existing pharmacophore to extend it by a measured, conformationally defined distance rather than a flexible chain.
- Stereochemically directed synthesis: because the material arrives with its trans relationship already established, it removes the need for a separate stereochemical resolution step in a multi-step route.
| Brand | TCI (Tokyo Chemical Industry) |
|---|---|
| CAS number | 3618-04-0 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in standard TCI research pack sizes; please confirm the required size when ordering. |
| Physical form | — |
| Storage | keep in a cool, dry place in the tightly closed original container, following the storage statement on the TCI label. |
- Product code: E0838
Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible reagents, and observe any specific storage temperature stated on the manufacturer's label. Keep the material in its original TCI container or in a clean, chemically compatible, clearly labelled vessel; hydroxyl-bearing esters are best protected from moisture and prolonged air exposure. Handle in a fume hood using safety glasses, gloves, and a laboratory coat. Weigh and transfer the compound with clean, dry equipment to avoid contamination, close the container promptly after use, and consult the manufacturer's safety data sheet before first handling. Dispose of residues and contaminated materials through the laboratory's chemical waste procedure.
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