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Description
Ethyl all cis-5,8,11,14,17-Eicosapentaenoate is the ethyl ester of eicosapentaenoic acid (EPA), one of the most extensively studied long-chain omega-3 fatty acids in nutritional and biomedical science. This product is supplied in a form stabilized with tocopherols in order to protect the polyene chain against oxidation. In the laboratory, the compound serves as a reference material and a test substance in lipidomics research, fatty acid metabolism studies, supplement formulation work, and investigations into the biological mechanisms that involve omega-3-derived lipid mediators.
The characteristic that determines its practical value is the structure of five non-conjugated double bonds in an all-cis configuration at positions 5, 8, 11, 14, and 17. This arrangement gives the molecule its distinctive conformational flexibility and underlies its role in biological membranes as well as in the biosynthetic pathways leading to eicosanoids and resolvins. At the same time, the high number of double bonds makes it highly susceptible to oxidation by atmospheric oxygen, light, and heat. The addition of tocopherols as an antioxidant helps slow that process so that the fatty acid profile remains intact throughout correct storage and handling.
In Indonesian laboratories, this material is typically used in academic and institutional research settings where omega-3 lipids are analysed or evaluated. It commonly appears in university and research-institute work on fatty acid metabolism, in lipidomics analysis, and in the development and evaluation of supplement formulations. Because the compound is oxidation-sensitive, laboratories working in a warm and humid tropical climate generally handle it with particular attention to temperature control, protection from light, and limited exposure to air during use.
Laboratory Applications
- Lipidomics research: the compound functions as a defined reference material for EPA ethyl ester, allowing analysts to identify and confirm this species within complex lipid profiles.
- Fatty acid metabolism studies: as a well-characterised long-chain omega-3 ester, it serves as a test substance for tracing how EPA is taken up, converted, and distributed in metabolic work.
- Supplement formulation development: it provides a consistent, tocopherol-stabilized EPA ethyl ester for formulation trials in which the fatty acid profile must remain intact during preparation.
- Lipid mediator mechanism studies: the all-cis pentaene structure makes it directly relevant to research on eicosanoid and resolvin biosynthetic pathways derived from omega-3 precursors.
- Membrane and biophysical studies: the conformational flexibility conferred by five non-conjugated cis double bonds supports investigations into the behaviour of polyunsaturated species in biological membranes.
Specifications
- Brand: TCI
- Catalogue code: E0853
- CAS number: 86227-47-6
- Category: Life Science > Biochemicals and Reagents > Lipids
- Composition note: supplied stabilized with tocopherols as an antioxidant
- Storage note: keep cool, protected from light, and away from heat; pack sizes are as listed by the manufacturer for this catalogue code
Handling and Storage
Store the product cool, in the dark, and away from sources of heat, since the five double bonds in the molecule make it highly susceptible to oxidation by atmospheric oxygen, light, and heat. Keep the material in its original tightly closed container, or in a comparable light-protecting, well-sealed vessel, and limit the time the container stands open during use so that air exposure remains minimal. Handle in a well-ventilated area with standard laboratory personal protective equipment, including gloves, eye protection, and a laboratory coat. Return the container to storage promptly after dispensing, and keep records of opening dates so that the integrity of the fatty acid profile can be assessed over the working life of the material.
