Ethyl 2-Amino-4-methylthiazole-5-carboxylate TCI E0898

Name: TCI E0898 7210-76-6 Ethyl 2-Amino-4-methylthiazole-5-carboxylate
Brand: TCI
SKU: TCI2510E089828715
Price: 1210650.0 IDR
Availability: InStock

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Berat 1g 5g

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Description

TCI E0898 Ethyl 2-Amino-4-methylthiazole-5-carboxylate is a heterocyclic building block based on a thiazole ring that carries three functional groups at once: a primary amine at position two, a methyl group at position four, and an ethyl ester at position five. This arrangement makes it one of the most practical starting materials in thiazole chemistry, because researchers can modify two sides of the molecule separately — through reactions at the amine and through transformations at the ester group. In synthetic laboratories, this compound usually serves as a core that is subsequently elaborated into amides, ureas, sulfonamides, or fused ring systems.

The property that makes it a frequent choice is the balance of reactivity between the aminothiazole amine, which is sufficiently nucleophilic yet remains controllable, and the ester, which can be hydrolysed to the carboxylic acid and then converted into an amide using ordinary coupling reagents. The thiazole ring itself is a pharmacophore that appears often in bioactive molecules, so derivatives prepared from this material frequently become interesting candidates in biological activity screening. Its solid form makes accurate weighing and long-term storage straightforward, and its stability supports routine handling on the bench.

In Indonesian laboratories, this building block is typically used in university and institutional research groups working on medicinal chemistry and heterocyclic synthesis, where a single reliable core can support several parallel derivative series. Because it is supplied as a solid, it suits laboratories that need to weigh out small portions repeatedly over an extended project period without preparing fresh stock each time, and it fits well into standard multi-step synthetic route development.

Laboratory Applications

Medicinal chemistry scaffold development — the thiazole ring is a recognised pharmacophore in bioactive molecules, so derivatives built on this core are frequently attractive candidates for biological activity screening programmes.
Amide library synthesis — the ethyl ester can be hydrolysed to the corresponding carboxylic acid and then coupled with a range of amines using ordinary coupling reagents to generate structurally varied analogues.
Urea and sulfonamide preparation — the primary amine at position two provides a direct handle for acylation-type chemistry, allowing researchers to install urea and sulfonamide linkages without protecting the ester.
Fused heterocyclic ring construction — the adjacent amine and ester functionality on the thiazole ring allow cyclisation strategies that build additional fused ring systems onto the existing thiazole core.
Orthogonal two-site derivatisation studies — because the amine and the ester can be addressed separately, this compound suits methodology work that requires modifying two positions of one molecule in sequence.

Specifications

Brand: TCI
CAS number: 7210-76-6
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Chemical name: Ethyl 2-Amino-4-methylthiazole-5-carboxylate
Physical form: solid
Pack sizes: available in the standard catalogue pack sizes offered for this item; please confirm the required quantity when ordering
Storage: keep in a tightly closed container in a cool, dry place away from light

Handling and Storage

Store the container tightly closed in a cool, dry, well-ventilated area, protected from direct light and away from sources of heat or ignition. The original supplier container is the preferred storage vessel; if transfer is necessary, use a chemically compatible, well-sealed amber glass or suitable plastic container that is clearly labelled with the compound name and CAS number. Handle the solid in a fume hood to avoid inhaling dust, and wear standard laboratory personal protective equipment including safety goggles, a laboratory coat, and chemically resistant gloves. Allow refrigerated material to reach room temperature before opening to prevent moisture condensation, and close the container promptly after weighing. Always consult the manufacturer safety data sheet before first use and dispose of residues in accordance with institutional chemical waste procedures.