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Description
TCI E1428, bearing CAS number 1366002-50-7, is Senexin A, a small-molecule research reagent known as an inhibitor of the cyclin-dependent kinase CDK8 together with its paralog CDK19. Unlike ordinary synthetic raw materials, this compound is prepared for molecular biology and pharmacology research purposes — that is, as a tool for disrupting one specific regulatory pathway inside the cell and then observing the consequences. Its role in the laboratory is to provide a means of chemical intervention that can be added directly to cell culture, so that researchers are able to test the involvement of the CDK8/CDK19 axis in transcription without having to carry out genetic engineering.
The characteristic that makes Senexin A a preferred choice is its targeting of the kinase module of the Mediator complex, the regulatory node that connects transcription factors with the RNA polymerase II machinery. In this way, the observed effects can be interpreted within the framework of transcriptional regulation rather than as general cell cycle inhibition alone. The compound is also widely cited in the literature as a comparator for subsequent generations of CDK8 inhibitors, so that experimental results are more readily compared against established work. This combination of a defined molecular target and an established position in the published record gives it a dependable reference value in experimental design.
In Indonesian laboratories, this material is typically used within university research groups, biomedical research institutes, and pharmacology units that carry out cell-based studies. It is generally applied in work examining transcriptional signalling, in mechanism-of-action studies supporting graduate and postgraduate research, and in screening exercises where a well-characterised chemical probe is needed as a point of reference. Because it is supplied as a research reagent, handling is normally managed by trained personnel under standard institutional laboratory practice.
Laboratory Applications
Transcriptional regulation studies — the compound acts on the Mediator complex kinase module, allowing researchers to probe how transcription factors communicate with the RNA polymerase II machinery in living cells.
CDK8/CDK19 pathway interrogation — because it inhibits both paralogs, it lets investigators test the involvement of this kinase axis without constructing knockout or knockdown cell lines first.
Cell culture intervention experiments — the reagent can be added directly to culture systems, giving a straightforward chemical means of perturbing one pathway and then observing the downstream cellular consequences.
Comparator and benchmarking work — it is widely referenced in the literature as a standard against which newer generations of CDK8 inhibitors are evaluated and compared.
Molecular pharmacology and mechanism-of-action research — as a defined small-molecule probe, it supports studies that need chemical intervention at a specific regulatory node rather than broad, non-selective inhibition.
Specifications
Brand: TCI
CAS number: 1366002-50-7
Chemical name: Senexin A
Product code: E1428
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes: available in the standard research-scale pack presentations offered by TCI for this catalogue item
Storage: follow the storage conditions stated on the manufacturer's label and accompanying documentation
Handling and Storage
Store the container in accordance with the conditions specified on the manufacturer's label, keeping it tightly closed and protected from moisture and direct light. Use the original supplier container wherever possible, or an equivalent tightly sealed, chemically compatible vessel that is clearly labelled with the product name, CAS number, and date of receipt. As with any research reagent, handle the material in a well-ventilated area or fume hood, wear appropriate personal protective equipment including gloves, safety glasses, and a laboratory coat, and avoid inhalation or contact with skin and eyes. This compound is intended for research use only and should not be used for diagnostic or therapeutic purposes. Consult the Safety Data Sheet before handling, and dispose of residues and contaminated materials through your institution's approved chemical waste procedures.
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