Senexin B is a small-molecule selective inhibitor of cyclin-dependent kinase 8 (CDK8) and its paralog CDK19, two enzymes that form part of the kinase module of the transcription-regulating Mediator complex. Unlike classical CDK inhibitors that target the drivers of the cell cycle, this compound acts at the level of gene expression control. In the laboratory it serves as a research tool for dissecting the role of induced transcription in tumour growth, inflammation, and the interaction between cancer cells and their surrounding microenvironment, supplied by TCI under catalogue number E1598 with CAS number 1449228-40-3.
The properties that make Senexin B a frequently chosen reagent are its improved selectivity and potency relative to earlier generations of related compounds, together with solubility and metabolic stability better suited to long-duration experiments. Because CDK8 and CDK19 are not essential for the survival of normal cells in many model systems, inhibiting them tends to produce effects that are more narrowly directed at particular transcriptional programmes, for example the Wnt/beta-catenin pathway and responses to cytokines. This allows researchers to observe changes in gene expression without immediately triggering widespread cell death, so the interpretation of results becomes sharper and more specific.
In Indonesian laboratories this material belongs to the life science and cell biology workflow, specifically within cancer research. It is typically used by university research groups, biomedical institutes, and molecular biology facilities working on cultured cell models, where a defined chemical probe is needed to separate transcriptional effects from general cytotoxicity. Because it is a research reagent rather than a routine consumable, it is usually ordered for a planned experimental series and handled under the supervision of trained personnel.
- Transcriptional regulation studies: the compound acts directly on the Mediator kinase module, allowing researchers to probe how induced gene expression programmes are assembled and sustained in living cells.
- Cancer cell biology research: because CDK8 and CDK19 influence tumour growth through transcription rather than through cell-cycle control, this inhibitor isolates a distinct layer of oncogenic signalling.
- Wnt/beta-catenin pathway investigation: selective inhibition allows changes in this specific transcriptional programme to be followed without the confounding effects of broad, non-selective kinase blockade.
- Inflammation and cytokine response assays: the compound modulates transcriptional responses to cytokines, making it suitable for experiments examining how inflammatory signals are translated into gene expression.
- Tumour microenvironment studies: its role as a research tool for dissecting cancer cell interactions with surrounding tissue supports co-culture and conditioned-medium experimental designs over extended periods.
| Brand | TCI, catalogue number E1598 |
|---|---|
| CAS number | 1449228-40-3 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Cell Biology > Cancer Research |
| Pack sizes | available in the catalogue pack sizes offered by TCI for this item; please confirm the required quantity when ordering |
| Physical form | — |
| Storage | store according to the conditions stated on the manufacturer's label and certificate of analysis |
- Product type: small-molecule selective CDK8/CDK19 inhibitor, supplied as a research reagent
Store the product in its original tightly closed container under the conditions specified on the manufacturer's label, protected from light, moisture, and elevated temperature. Prepared stock solutions should be kept in clean, chemically compatible vials, clearly labelled with the compound name, concentration, solvent, and date, and divided into single-use aliquots to limit repeated freeze-thaw cycles. Handle the material in a well-ventilated area or fume hood using gloves, a laboratory coat, and eye protection, and avoid inhalation of dust or contact with skin. As with any research chemical, consult the safety data sheet before use, keep it away from incompatible substances, and dispose of residues and contaminated consumables through the laboratory's approved chemical waste stream.
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