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Description
TCI E1475 Ethopabate is a substituted methyl benzoate derivative bearing an acetamido group and a propoxy group on its aromatic ring. It is widely known in the animal health field as the active ingredient of a coccidiostat, commonly used together with amprolium in poultry. Supplied by TCI under the non-heterocyclic building blocks category, this compound is most often used in the laboratory as a reference material and a research starting material rather than as a general synthetic reagent. Its role is important in the development of analytical methods for veterinary drug residues in poultry tissue, eggs, and feed, a topic that remains a continuing concern in food quality surveillance.
The properties that make it useful begin with a clearly defined aromatic framework carrying chromophoric groups that give strong ultraviolet absorption, so the compound is readily detected by liquid chromatography with UV detection as well as by mass spectrometry. The combination of amide and ester functionalities provides a distinctive spectroscopic fingerprint in infrared and nuclear magnetic resonance analysis, making confirmation of identity straightforward. From a medicinal chemistry point of view, the structure is also of interest because it illustrates how inhibition of the folic acid pathway in parasites can be approached through analogues of that pathway's substrates, giving the material value as a teaching and comparison structure.
In Indonesian laboratories, this compound is typically encountered in food safety and veterinary residue testing work, in university research groups studying analytical chemistry and medicinal chemistry, and in quality control units that must verify chromatographic methods against a well-characterised reference substance. Because the poultry sector is a significant part of the national food supply, residue method development for compounds of this class is a recurring requirement in both government-linked testing laboratories and private analytical service providers.
Laboratory Applications
Veterinary drug residue method development: serves as the reference substance against which extraction, clean-up, and chromatographic separation steps are optimised for poultry tissue, egg, and feed matrices.
Liquid chromatography with UV detection: the chromophoric aromatic framework produces strong ultraviolet absorption, allowing the compound to be tracked reliably through method validation and routine confirmation runs.
Mass spectrometric confirmation work: the defined molecular structure supports its use as a confirmatory reference in LC-MS based residue analysis, where identity must be established beyond retention time alone.
Spectroscopic identity confirmation studies: the combined amide and ester groups give characteristic infrared and nuclear magnetic resonance signals, making the material suitable for structural teaching and identity-checking exercises.
Medicinal chemistry and synthetic starting material research: the substituted benzoate scaffold illustrates folic acid pathway inhibition in parasites and serves as a starting point for analogue preparation.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 59-06-3
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Product code: E1475
Pack sizes: available in standard TCI research and reference quantities; please confirm the pack size required when ordering
Storage: store in a tightly closed container in a cool, dry, well-ventilated place away from light
Handling and Storage
Store the material in its original tightly closed container, in a cool, dry, and well-ventilated area, protected from direct sunlight and from sources of heat or ignition. Amber glass or the supplier's original packaging is suitable for keeping the contents dry and shielded from light. Handle the substance in a fume hood or a well-ventilated workspace, and wear a laboratory coat, chemical-resistant gloves, and safety glasses when weighing or transferring it. Avoid generating dust, avoid inhalation and skin contact, and keep containers closed when not in active use. Wash hands thoroughly after handling, keep the material away from incompatible substances, and dispose of residues and contaminated materials in accordance with applicable laboratory waste procedures. Always consult the safety data sheet supplied with the product before first use.
