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Description
D-Glucuronamide is the amide derivative of D-glucuronic acid, a sugar acid that plays a central role in the body's detoxification metabolism and serves as a building block of many important polysaccharides such as hyaluronic acid and heparin. In this compound, the carboxylic acid group of glucuronic acid has been converted into an amide group, so that its chemical character becomes neutral and it displays a different hydrogen bonding pattern. Supplied under the TCI brand, the material belongs to the glycoscience segment of chemical biology and is handled as a laboratory research chemical rather than a bulk reagent.
The properties that make this compound a preferred choice are its good solubility in water, thanks to the large number of hydroxyl groups it carries, its neutral character, which removes the negative charge typical of glucuronic acid, and its amide group, which serves as an entry point for a wide range of further chemical modifications. This change from acid to amide allows researchers to study directly how large a role the carboxylate charge plays in sugar binding by enzymes and receptors, an approach that is common in structure–activity relationship studies. The combination of water solubility and a chemically addressable handle makes the material flexible in synthetic and analytical work alike.
In Indonesian laboratories, the compound is used in university and institutional research settings where carbohydrate chemistry, glycoconjugate synthesis, and metabolism studies are carried out. It is applied as a starting material and intermediate in the synthesis of glycoconjugates, as a reference standard in the analysis of glucuronate derivatives, and as a test compound in research on metabolism and on carbohydrate recognition by proteins. Typical users are synthetic chemistry, biochemistry, and analytical groups working on modest research scales.
Laboratory Applications
- Glycoconjugate synthesis: the compound serves as a starting material and intermediate, with its amide group providing a defined entry point for building more complex sugar-containing structures.
- Analysis of glucuronate derivatives: it is used as a reference standard, allowing analysts to compare and confirm the identity of glucuronate-related species encountered in their sample sets.
- Metabolism research: as a test compound it lets investigators examine processes connected to glucuronic acid, the sugar acid central to the body's detoxification metabolism, under controlled laboratory conditions.
- Carbohydrate recognition studies: it acts as a test compound for research into how proteins recognise and bind sugars, where its neutral character differentiates it from the parent acid.
- Structure–activity relationship work: converting the acid to an amide removes the carboxylate charge, so researchers can measure directly how much that charge contributes to binding by enzymes and receptors.
Specifications
- Brand: TCI, catalogue number G0223
- CAS number: 3789-97-7
- Category: Chemistry > Chemical Biology > Glycoscience
- Chemical identity: amide derivative of D-glucuronic acid, neutral rather than acidic in character
- Pack sizes: research-scale packaging as offered by the manufacturer; please confirm available sizes when ordering
- Storage: follow the conditions stated on the manufacturer's label and safety data sheet
Handling and Storage
Store the material in its original tightly closed container, kept in a cool, dry, and well-ventilated place away from direct sunlight and sources of heat or moisture. Because the compound carries many hydroxyl groups and dissolves readily in water, containers should be resealed promptly after each use to limit exposure to atmospheric humidity. Handle it in a clean laboratory area using standard personal protective equipment, including a laboratory coat, safety glasses, and suitable gloves, and weigh out portions with clean, dry spatulas to avoid contamination of the stock. Always consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials in accordance with local laboratory waste regulations.
