TCI
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Description
Glycidyl Isopropyl Ether is an aliphatic epoxide compound that combines a strained oxirane ring with an isopropyl ether group on its side chain. The epoxide ring is one of the most useful functional groups in organic synthesis because it is readily opened by a wide range of nucleophiles such as amines, thiols, alcohols, and carbanions, producing products bearing a new hydroxyl group at a predictable position. In the laboratory, this material serves as a hydroxyalkylating reagent, a side-chain extender, and a reactive diluent in research-scale epoxy resin formulations.
The characteristics that make this compound a preferred choice are its high yet controllable reactivity, combined with a low viscosity that makes it easy to transfer and measure as a liquid. The isopropyl ether group is chemically inert and does not participate in the reaction, but it contributes sufficient lipophilicity and lowers the viscosity of both reaction mixtures and resin formulations. Its epoxide ring opening proceeds with regioselectivity that depends on acidic or basic conditions, giving researchers control over the structure of the final product. As a monofunctional monoepoxide, the compound is also useful for terminating chains and regulating crosslink density.
In Indonesian laboratories, this building block is typically used in academic and industrial research settings working on organic synthesis, polymer chemistry, and coatings development. University research groups and institutional laboratories select it for exploratory reactions where a small, well-behaved epoxide is needed to introduce a hydroxy-ether motif. It is equally at home in formulation laboratories evaluating epoxy systems at bench scale, where the material's handling convenience suits the modest working quantities typical of Indonesian research facilities.
Laboratory Applications
- Hydroxyalkylation of nucleophiles: the strained oxirane ring reacts cleanly with amines, thiols, and alcohols to install a new hydroxyl group at a predictable position on the target molecule.
- Reactive diluent in epoxy resin formulations: its low viscosity reduces the overall viscosity of research-scale resin systems while the epoxide group still participates chemically in the curing network.
- Chain terminator and crosslink density control: as a monofunctional monoepoxide it caps growing chains, allowing researchers to deliberately regulate network density in polymer studies.
- Side-chain extension in organic synthesis: the compound introduces a hydroxy-ether fragment that lengthens a side chain and adds lipophilic character without contributing additional reactive sites.
- Regioselectivity studies of epoxide ring opening: because attack position shifts under acidic versus basic conditions, the material is a convenient substrate for mechanistic and methodology investigations.
Specifications
- Brand: TCI
- CAS number: 4016-14-2
- Catalogue number: G0255
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Physical form: liquid, low viscosity
- Pack sizes: available in standard TCI research-scale packaging; please confirm the size required when ordering
- Storage: keep in a cool, well-ventilated area in a tightly closed original container
Handling and Storage
Store the material in a cool, dry, and well-ventilated place, away from heat sources, direct sunlight, and open flame. Keep the container tightly closed in its original packaging to limit exposure to air and moisture, and store it separately from strong acids, strong bases, and oxidising agents, since these can initiate uncontrolled ring-opening of the epoxide. Handle all transfers inside a fume hood using chemically resistant gloves, safety goggles, and a laboratory coat, and avoid inhaling vapours or allowing contact with skin and eyes. Use clean, dry glassware or compatible solvent-resistant equipment when dispensing, label all working aliquots clearly, and consult the manufacturer's safety data sheet before first use.
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