(R)-Glycidyl Trityl Ether TCI G0284

Name: TCI G0284 65291-30-7 (R)-Glycidyl Trityl Ether
Brand: TCI
SKU: TCI2510G028431927
Price: 1270500.0 IDR
Availability: InStock

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Berat 5g 25g

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Description

(R)-Glycidyl Trityl Ether is a glycidol derivative in the (R) configuration whose primary hydroxyl group is protected by a triphenylmethyl, or trityl, group. In asymmetric synthesis laboratories, this compound serves as a chiral starting material that arrives with its protection strategy already in place, allowing researchers to work directly on the epoxide ring without concern that the hydroxyl group will react alongside it. This approach saves working steps, suppresses the risk of side reactions, and simplifies the design of multistep synthetic routes toward target molecules that demand high optical purity.

The property behind its selection is the character of the trityl group, which is sterically bulky yet readily removed under mild acidic conditions, so it acts as an orthogonal protecting group relative to many other protecting groups. The large size of the trityl group can also influence the direction of nucleophilic attack on the oxirane ring, thereby assisting regioselectivity. Unlike several other glycidyl ethers that exist as liquids, this compound is generally a crystalline solid, which is advantageous because it is easy to weigh, easy to purify by recrystallization, and relatively comfortable to handle at the bench.

Organic chemistry research groups in Indonesia typically reach for this material when a synthetic route calls for a chiral three-carbon fragment with a defined stereocenter and a protected terminal alcohol. Its solid form suits the weighing and transfer practices common in university and institutional laboratories, and its orthogonal deprotection behaviour fits multistep work where several protecting groups must be removed selectively at different stages of a planned sequence.

Laboratory Applications

Asymmetric synthesis route development, where the defined (R) stereocentre supplies optical information to the target molecule without requiring a separate resolution or chiral auxiliary step.
Regioselective epoxide ring-opening studies, because the bulky trityl group can steer the direction of nucleophilic attack on the oxirane ring and influence which carbon is attacked.
Multistep synthesis of optically active target molecules, since the pre-installed protection allows the epoxide to be manipulated first while the primary hydroxyl remains untouched throughout the sequence.
Orthogonal protecting group strategy work, as the trityl group is removed under mild acidic conditions and therefore survives many conditions that cleave other common protecting groups.
Preparation of chiral building block libraries, where the crystalline solid form makes accurate weighing, recrystallisation, and repeated small-scale dispensing straightforward compared with liquid glycidyl ether analogues.

Specifications

Brand: TCI
Product code: G0284
CAS number: 65291-30-7
Category: Chemistry > Asymmetric Synthesis > Chiral Building Blocks
Physical form: generally a crystalline solid
Storage: store in a tightly closed container in a cool, dry place away from light and moisture

Handling and Storage

Store the material in a tightly closed original container in a cool, dry, well ventilated place, protected from direct light and moisture, and keep it away from acids since the trityl protecting group is cleaved under acidic conditions. Amber glass or the supplier's own container is suitable, and the container should be resealed promptly after each use to limit moisture pickup. Weigh and transfer the solid in a fume hood using gloves, safety glasses, and a laboratory coat, avoid inhalation of dust and contact with skin or eyes, and keep the compound separate from strong acids and strong oxidising agents. Consult the manufacturer's safety data sheet before use and follow the disposal rules that apply in your laboratory.