Hydrochlorothiazide TCI H1274

Hydrochlorothiazide with CAS number 58-93-5 is a benzothiadiazine-class compound supplied by TCI as a pharmaceutical research reagent intended for laboratory experimental use. The molecule is built on a heterocyclic framework containing both sulfur and nitrogen atoms, carrying a sulfonamide group and a chlorine atom on its aromatic ring. In the laboratory setting, this material serves as a reference compound in analytical method development, as a test substance in formulation research, and as a subject of study in medicinal chemistry work examining structure-activity relationships across the thiazide class of compounds.

The characteristics that make this compound important to researchers are its well-defined molecular structure and its extensive documentation throughout the scientific literature, which means spectroscopic and chromatographic data generated in-house can be readily compared against published values. The presence of the sulfonamide group confers weakly acidic character that influences solubility and the behaviour of the compound across a range of pH conditions — an aspect highly relevant to the development of liquid chromatography methods as well as to dissolution studies. Reagent-grade quality from TCI provides the consistency required when this compound is used as a comparator.

In Indonesian laboratories, this reagent is typically used in university pharmacy and chemistry departments, pharmaceutical quality control laboratories, and research institutions carrying out analytical and formulation work. It supports routine method development activities where a reliably characterised reference material is needed, and it is applied in academic research programmes investigating thiazide-class compounds. Its role is confined to experimental laboratory use rather than any clinical or therapeutic application.

• Analytical method development — serves as a reference compound whose well-documented spectroscopic and chromatographic data allow newly developed procedures to be checked against established literature values.
• Liquid chromatography method optimisation — the weakly acidic sulfonamide group makes pH-dependent retention behaviour a useful variable when developing and refining mobile phase conditions.
• Formulation research — functions as a test substance in studies examining how a defined benzothiadiazine compound behaves within different experimental preparation systems under laboratory conditions.
• Dissolution studies — its pH-dependent solubility behaviour, arising from the sulfonamide functionality, makes it a suitable subject for investigating dissolution profiles across varying media conditions.
• Medicinal chemistry research — acts as a study object in structure-activity relationship investigations of thiazide-class compounds, supported by its clearly defined heterocyclic molecular framework.

• Product code: H1274

Store this reagent in its original tightly closed container in a cool, dry, well-ventilated area away from direct sunlight, moisture, and incompatible materials, following the storage conditions specified on the manufacturer's label and safety data sheet. Suitable containers are the original supplier packaging or chemically compatible tightly sealed glass containers with clear labelling. Handle the material in a laboratory equipped with adequate ventilation or within a fume hood, and wear appropriate personal protective equipment including a laboratory coat, chemical-resistant gloves, and safety eyewear. Avoid generating dust, avoid inhalation and skin contact, and wash hands thoroughly after handling. Consult the safety data sheet before use and dispose of residues in accordance with applicable laboratory waste procedures. This material is intended for experimental laboratory use only.

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