TCI M1065 is 1-(4-Methylphenoxy)-2-propanol, an aryl ether compound formed from a p-cresol skeleton linked to a propanol chain bearing a secondary hydroxyl group. It is classified as a non-heterocyclic building block, a category of materials supplied specifically for stepwise synthesis work in organic chemistry laboratories. Its function is not that of a finished product but rather as a molecular foundation that will be elaborated into a target compound, whether in medicinal chemistry research, functional materials development, or reaction methodology studies that require a simple and well-defined substrate.
The advantage of this compound lies in its structural simplicity, which in fact grants researchers considerable freedom. The methyl group at the para position is a weak electron donor and creates no steric hindrance around the ether oxygen, so the reactivity of the aromatic ring can be predicted reliably. The secondary hydroxyl group provides a single, clearly defined reaction site, making the selectivity of transformations easier to control than with substrates carrying multiple competing functional groups. The aryl ether linkage is also resistant to a range of basic conditions, which broadens the set of reaction sequences the material can survive.
In Indonesian laboratories, this type of building block is typically used in university research groups and institutional synthesis facilities where target molecules are assembled step by step from defined starting materials. It suits work programmes that require predictable substrates for route development, comparative method studies, and the preparation of derivatives. Because the compound is supplied as a catalogue building block rather than a formulation, it fits naturally into ongoing synthetic projects where the researcher defines the downstream chemistry.
- Medicinal chemistry intermediate preparation: the defined aryl ether core and single secondary hydroxyl allow researchers to elaborate the scaffold into candidate structures without competing functional group interference.
- Reaction methodology studies: its structural simplicity and predictable aromatic reactivity make it a clean model substrate when evaluating new transformations or comparing catalytic conditions side by side.
- Functional materials development: the p-cresol-derived aryl ether framework serves as a molecular foundation that can be extended into larger structures designed for specific material properties.
- Derivative synthesis at the hydroxyl position: the secondary alcohol offers one unambiguous reaction site, so esterification, etherification, or oxidation sequences proceed with straightforward selectivity control.
- Multi-step synthetic route development: resistance of the aryl ether bond to a range of basic conditions lets the fragment carry through several stages without premature cleavage of the linkage.
| Brand | TCI (Tokyo Chemical Industry) |
|---|---|
| CAS number | 4369-08-8 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in standard TCI research catalogue packaging; please confirm the size required when ordering |
| Physical form | — |
| Storage | keep in the tightly closed original container as indicated on the manufacturer's label |
- Chemical name: 1-(4-Methylphenoxy)-2-propanol
Store the material in its original tightly closed container, kept upright in a cool, dry, well-ventilated chemical store away from direct sunlight, heat sources, and strong oxidising agents. Follow the storage conditions stated on the manufacturer's label and safety data sheet, as these take precedence over general guidance. Handle inside a fume hood using safety glasses, chemical-resistant gloves, and a laboratory coat. Avoid inhalation of vapours and contact with skin and eyes. Close the container immediately after weighing to limit moisture uptake and evaporation, label any secondary containers clearly, and dispose of residues and contaminated materials through the institution's approved chemical waste channel.
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