2-Mercapto-5-methoxybenzimidazole is a bifunctional heterocyclic compound that combines a benzimidazole ring with a mercapto group at the 2-position and a methoxy group on the benzene ring. The benzimidazole framework is widely recognised as an important structural motif in medicinal chemistry and coordination chemistry. In the laboratory, this compound serves as a heterocyclic building block: an intermediate that supplies a ready-made molecular core together with reactive groups already in place, so that researchers can construct target structures directly instead of assembling the fused ring system from simpler starting materials.
The characteristic that makes this material so widely used is the presence of three distinct types of reactive site within a single molecule. The mercapto group at the 2-position is strongly nucleophilic and undergoes S-alkylation very readily with benzylic and alkyl halides, giving thioether derivatives in good yield under mildly basic conditions. The benzimidazole nitrogen can be alkylated or can act as a donor atom in the formation of metal complexes. The methoxy group, meanwhile, modulates the electron density of the ring and imparts a distinctive substitution pattern to the final product. The compound also exhibits thiol–thione tautomerism.
In Indonesian laboratories, this building block is typically encountered in university research groups, postgraduate synthesis work, and institutional research units engaged in medicinal chemistry and coordination chemistry programmes. It is used where a benzimidazole core with a defined substitution pattern is required as the starting point of a synthetic route, and where the availability of several orthogonal reactive sites allows a single common intermediate to be diversified into a series of related target compounds.
Related TCI products
- TCI H1547 67021-83-4 4-Hydroxybenzimidazole
- TCI H0739 615-16-7 2-Hydroxybenzimidazole
- TCI A0425 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole
- TCI A1455 16691-43-3 3-Amino-5-mercapto-1,2,4-triazole
- TCI A0956 1750-12-5 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole [for Determination of Aldehydes]
- TCI P0640 86-93-1 5-Mercapto-1-phenyl-1H-tetrazole
- S-Alkylation to thioether derivatives: the nucleophilic 2-mercapto group reacts readily with benzylic and alkyl halides under mildly basic conditions, producing thioether products in good yield.
- Medicinal chemistry intermediate synthesis: the benzimidazole framework is an established structural motif in medicinal chemistry, making this compound a direct entry point into biologically oriented target molecules.
- Metal complex preparation: the benzimidazole nitrogen can act as a donor atom, allowing this building block to be used in coordination chemistry studies and complex formation work.
- N-Alkylation and ring functionalisation: the benzimidazole nitrogen can be alkylated selectively, giving researchers a second reactive handle for elaborating the heterocyclic core.
- Library synthesis from a common core: three distinct reactive site types in one molecule let a single intermediate be diversified into a series of structurally related target compounds.
| Brand | TCI |
|---|---|
| CAS number | 37052-78-1 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | available in the standard research pack sizes offered by TCI for this catalogue item |
| Physical form | — |
| Storage | store according to the conditions stated on the manufacturer's label and safety data sheet |
- Catalogue number: M1256
- Chemical name: 2-Mercapto-5-methoxybenzimidazole
Store the container tightly closed in a cool, dry, well-ventilated area, away from heat sources, direct sunlight, and incompatible materials such as strong oxidising agents. Keep the compound in its original manufacturer's container, or in a clean, clearly labelled amber glass or chemically compatible container if transferred. As with all mercapto-containing compounds, handle in a fume hood to limit exposure to odour and dust, and wear standard laboratory personal protective equipment including a lab coat, safety glasses, and chemically resistant gloves. Weigh out material carefully to avoid generating airborne powder, close the container promptly after use, and consult the manufacturer's safety data sheet before handling, storage, and disposal.
—
Produk Terkait
-
4-Hydroxybenzimidazole TCI H1547
Regular price From Rp 2.306.850,00Regular price -
2-Hydroxybenzimidazole TCI H0739
Regular price Rp 2.411.850,00Regular price -
2-Amino-5-mercapto-1,3,4-thiadiazole TCI A0425
Regular price From Rp 769.650,00Regular price -
3-Amino-5-mercapto-1,2,4-triazole TCI A1455
Regular price From Rp 980.700,00Regular price -
4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole[forDeterminationofAldehydes] TCI A0956
Regular price From Rp 1.670.550,00Regular price -
5-Mercapto-1-phenyl-1H-tetrazole TCI P0640
Regular price From Rp 875.700,00Regular price -
2-Mercapto-6-nitrobenzothiazole TCI N0326
Regular price From Rp 2.016.000,00Regular price -
(5-Mercapto-1,3,4-thiadiazol-2-ylthio)aceticAcid TCI M2100
Regular price From Rp 1.458.450,00Regular price
![1750-12-5 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole [for Determination of Aldehydes] - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510A0956.jpg?v=1767080402&width=533)
