Methyl 2-Oxo-1-pyrrolidineacetate TCI O0205

Methyl 2-Oxo-1-pyrrolidineacetate from TCI (product code O0205) is the methyl ester of 2-oxo-1-pyrrolidineacetic acid. It is a pyrrolidone (γ-lactam) derivative with an acetate group on the nitrogen atom. The compound is a heterocyclic building block used widely in organic synthesis and pharmaceutical chemistry. It is best known as a precursor to the racetam family of compounds: amidation of its ester group gives the 2-oxo-1-pyrrolidineacetamide framework, which is the core of piracetam. This makes it a practical starting material in research laboratories.

Chemists choose this material because it combines a stable lactam ring with a methyl ester group that is easy to modify. The ester can be hydrolysed to the corresponding acid, reacted with amines to form amides, or reduced to an alcohol, so one starting compound can lead to many derivatives. The pyrrolidone ring adds polarity and can accept hydrogen bonds, which are properties often sought in bioactive molecule design. Because it is supplied at reagent-grade purity, researchers can get reproducible results and characterise the derivatives they make more easily.

In Indonesian laboratories, this material is relevant to medicinal chemistry research groups in pharmacy faculties and to organic synthesis laboratories at universities and research institutions. Researchers who study racetam analogues, design new heterocyclic scaffolds, or train students in ester transformation reactions will find it a convenient, well-defined starting point. It also suits student theses and final-year projects that need a reliable heterocyclic intermediate from a recognised brand, and pharmaceutical development teams that explore structure–activity relationships of pyrrolidone-based compounds.

• Racetam precursor synthesis: amidation of the methyl ester gives the 2-oxo-1-pyrrolidineacetamide framework, so this compound is a direct and well-known route to piracetam-type structures.
• Amide library preparation: the ester reacts with many primary and secondary amines, so researchers can build a series of N-substituted pyrrolidone acetamides from one heterocyclic starting material.
• Carboxylic acid generation: hydrolysis of the ester gives 2-oxo-1-pyrrolidineacetic acid, which can then take part in coupling reactions and other acid-based transformations in multistep synthesis.
• Alcohol derivative synthesis: reducing the ester group gives the corresponding alcohol, which extends the range of pyrrolidone-containing intermediates available for further functionalisation in organic chemistry work.
• Medicinal chemistry scaffold design: the polar pyrrolidone ring accepts hydrogen bonds, which makes this building block useful for designing and optimising bioactive molecules in drug discovery research.

• Grade: reagent-grade purity, suitable for research synthesis

Keep this compound in its original, tightly closed manufacturer's container, in a cool, dry, well-ventilated place away from direct sunlight, heat sources, and incompatible materials such as strong oxidising agents, acids, and bases. Reseal the container promptly after each use to limit exposure to moisture and air. Handle the material in a fume hood or well-ventilated area, and wear standard personal protective equipment, including a laboratory coat, safety glasses, and chemical-resistant gloves. Avoid contact with skin and eyes and do not breathe in vapours. Always check the Safety Data Sheet supplied with the product for detailed hazard, first-aid, and disposal information, and dispose of waste according to institutional and local regulations.

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