Paroxetine Hydrochloride Hemihydrate TCI P1977

Chemical Identity

CAS No.: 110429-35-1
PubChem: CID 62878·SID 135727290
Formula: C19H21ClFNO3
Molecular weight: 365.8 g/mol
Purity: >98.0%(HPLC)(T)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride
SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl
InChIKey: GELRVIPPMNMYGS-RVXRQPKJSA-N

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TCI P1977 Paroxetine Hydrochloride Hemihydrate is the hydrochloride hemihydrate salt of paroxetine, a compound in the selective serotonin reuptake inhibitor (SSRI) class. It is supplied as a pharmaceutical research reagent for experimental use only, not for therapeutic use. In the laboratory, paroxetine is used as a pharmacological tool for studying the serotonin system, as a reference material in drug analysis, and as a model compound in studies of drug metabolism and drug interactions. Researchers working on neurotransmission, transporter biology, and analytical pharmaceutical chemistry use it as a well-characterised point of comparison.

Paroxetine is known as a very potent and selective inhibitor of the serotonin transporter. For this reason it is often chosen as the comparator compound in transporter binding assays and functional transporter assays, where a dependable positive control is needed. It is also known to inhibit the cytochrome P450 2D6 enzyme, which makes it relevant to in vitro drug interaction studies. The hemihydrate is a well-defined solid form, which helps keep weighing and solution preparation consistent from batch to batch. TCI quality helps make research data comparable with published literature, so results can be checked against earlier studies with confidence.

In Indonesia, neuropharmacology research, analytical pharmaceutical chemistry, and drug quality control all regularly need reference compounds such as paroxetine. University pharmacy and pharmacology departments use it in teaching and thesis research on serotonergic mechanisms and on analytical method development. Research institutes and quality control laboratories use it as a comparison standard when building and validating analytical procedures for pharmaceutical samples. Because the reagent comes from TCI, results produced in Indonesian laboratories can be compared with international literature.

TCI brochures (PDF)

Neurotransmission Research Reagents 2026-07-17 · p. 1
Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 29

Related TCI products

Serotonin system research: paroxetine serves as a potent, selective serotonin transporter inhibitor, letting researchers probe serotonergic signalling and reuptake mechanisms under controlled experimental conditions.
Transporter binding and functional assays: its strong selectivity for the serotonin transporter makes it a common reference comparator for judging the potency and selectivity of new test compounds.
In vitro drug interaction studies: because paroxetine is known to inhibit cytochrome P450 2D6, it is relevant for studying enzyme inhibition and possible metabolic interactions between drug candidates.
Drug metabolism studies: as a well-characterised model compound, paroxetine helps researchers set up and compare metabolic pathway experiments with existing literature data.
Analytical reference material: the well-defined hemihydrate solid form supports consistent weighing and solution preparation, which suits method development, validation, and drug quality control work.

Brand	TCI (product code P1977)
CAS number	110429-35-1
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack sizes	available in TCI standard pack sizes; please confirm the options with AMI Scientific
Physical form	solid, hydrochloride hemihydrate salt form
Storage	follow the storage conditions on the TCI label and Safety Data Sheet

Keep Paroxetine Hydrochloride Hemihydrate in its original tightly closed container in a cool, dry, well-ventilated place, away from direct light, moisture, and incompatible materials. Follow the storage conditions on the TCI product label and Safety Data Sheet. Close the container promptly after each use to protect the defined hemihydrate form from changes in humidity. Because it is a pharmacologically active compound, handle it only in the laboratory, wearing gloves, safety glasses, and a lab coat, and avoid inhaling dust or letting it touch your skin. Weigh it in a fume hood or a ventilated balance enclosure. Label all prepared solutions clearly, and dispose of waste according to institutional and local regulations. For experimental use only, not for human or veterinary use.

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