(S)-(+)-Rolipram TCI R0183

Chemical Identity

CAS No.: 85416-73-5
PubChem: CID 158758·SID 354333407
Formula: C16H21NO3
Molecular weight: 275.34 g/mol
Purity: >98.0%(HPLC)
Reference databases: ChEBI·ChemSpider

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
SMILES: COC1=C(C=C(C=C1)[C@@H]2CC(=O)NC2)OC3CCCC3
InChIKey: HJORMJIFDVBMOB-GFCCVEGCSA-N

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(S)-(+)-Rolipram is a chemical compound widely used in biochemical and pharmacological research. As a selective inhibitor of phosphodiesterase type 4 (PDE4), it plays a crucial role in studying the mechanisms of drug action and their effects on the nervous system. This compound is essential for investigating the biological effects on cells and tissues, particularly in research related to neurodegenerative diseases and mental disorders. Its specific activity and stability under controlled conditions make it a valuable tool for researchers seeking precise and reliable results.

The compound is known for its high chemical stability and purity, which ensures consistent performance across various experimental setups. Its solubility in organic solvents makes it suitable for use in analytical techniques such as chromatography and spectroscopy. Additionally, (S)-(+)-Rolipram maintains its biological activity under controlled laboratory conditions, minimizing the risk of measurement errors. These properties make it a preferred choice for scientists requiring accuracy and reproducibility in their experiments.

In Indonesian laboratories, (S)-(+)-Rolipram is widely used in academic and research institutions. Its application in studying the pharmacological effects of drugs and the role of PDE4 in neurological functions has made it a standard reagent in many research projects. Researchers rely on its reliability and consistency to obtain accurate data, contributing to advancements in biomedical science.

TCI brochures (PDF)

Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 30

Related TCI products

Neuropharmacological research benefits from (S)-(+)-Rolipram's ability to inhibit PDE4, aiding in the study of neurotransmitter regulation and cognitive function.
It is used in the investigation of neurodegenerative diseases due to its impact on inflammatory pathways and neuronal survival.
The compound supports studies on mental disorders by analyzing the role of PDE4 in mood regulation and synaptic plasticity.
It is essential in biochemical assays where precise enzyme inhibition is required for accurate data interpretation.
(S)-(+)-Rolipram is applied in drug development to evaluate the efficacy and mechanism of action of potential therapeutic agents.

Brand	TCI
CAS number	85416-73-5
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Enzymes, Enzyme Inhibitors, Enzyme Substrates
Pack sizes	Available in various quantities as per standard laboratory requirements
Physical form	Solid powder
Storage	Store in a cool, dry place away from light and moisture

(S)-(+)-Rolipram should be stored in a cool, dry place, away from light and moisture to maintain its chemical stability and potency. It is recommended to use airtight containers to prevent exposure to humidity and contaminants. Due to its chemical nature, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure laboratory safety. The compound is non-hazardous under normal conditions but should be stored separately from incompatible substances. Regular monitoring of storage conditions is advised to ensure the integrity of the product during long-term use. Proper labeling and documentation of storage locations are essential for safe and efficient laboratory operations.

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