• TCI T0431 76-05-1 Trifluoroacetic Acid
  • 76-05-1 Trifluoroacetic Acid - AMI Scientific
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TCI

CAS 76-05-1

Trifluoroacetic Acid TCI T0431

Trifluoroacetic Acid TCI T0431

Chemical Identity

Other names
= TFA · TFA
CAS No.
76-05-1
PubChem
CID 6422·SID 87576383
Formula
C2HF3O2
Molecular weight
114.02 g/mol
Purity
>99.0%(T)
Reference databases
ChEBI·ChemSpider·ECHA·Wikipedia
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
2,2,2-trifluoroacetic acid
SMILES
C(=O)(C(F)(F)F)O
InChIKey
DTQVDTLACAAQTR-UHFFFAOYSA-N
Rp 557.550,00
Rp 405.300,00 Rp 557.550,00
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Trifluoroacetic acid (TFA) is a powerful chemical compound widely used in various laboratory applications, particularly in organic chemistry and biochemical research. As a strong acid, it plays a critical role in molecular modification processes, including drying, separation, and structural alteration of organic compounds. Its high reactivity and ability to create extreme reaction conditions make it an essential reagent in advanced chemical synthesis. TFA is also a key component in glycoscience, where it supports chemical reactions involving glycosides or glycans. Its unique properties enable it to facilitate complex transformations that are otherwise difficult to achieve in standard laboratory settings.

One of the main reasons TFA is preferred in laboratories is its high polarity and strong ionization capability. These characteristics make it highly effective in altering the structure of organic compounds. Additionally, TFA exhibits excellent solubility in organic solvents, which simplifies dissolution and reaction processes. Its strong acidic nature allows it to act as a catalyst or reagent in a wide range of chemical reactions, making it versatile for different experimental needs. The consistency of its performance and reliability in various experimental conditions further solidify its position as a valuable laboratory reagent.

In Indonesian laboratories, TFA is commonly used in biochemical research, pharmaceutical chemistry, and the analysis of complex compounds. Its availability and consistent performance make it a preferred choice for researchers working on advanced chemical synthesis and molecular modification. Due to its broad applications, TFA remains a fundamental reagent in both academic and industrial research settings across Indonesia.

TCI brochures (PDF)

Related TCI products

  • Biochemical research utilizes TFA for molecular modification and structural analysis due to its strong acidic properties and ability to create extreme reaction conditions.
  • Pharmaceutical chemistry benefits from TFA’s solubility and reactivity in synthesizing complex organic compounds and modifying drug molecules.
  • Glycoscience applications rely on TFA for supporting chemical reactions involving glycosides and glycans, enhancing the efficiency of carbohydrate-related studies.
  • Analytical chemistry employs TFA for its effectiveness in dissolving and reacting with complex organic compounds, aiding in the analysis of various substances.
  • Organic synthesis experiments use TFA as a catalyst or reagent to facilitate challenging chemical transformations under extreme conditions.

From the TCI brochure

  • Additive in the reductive cross-electrophile coupling conditions (Zn, NaI, TFA, DMA, 80˚C)

Brand TCI
CAS number 76-05-1
Molecular formula —
Purity —
Category Chemistry > Chemical Biology > Glycoscience
Pack sizes Available in various sizes as per standard laboratory supply
Physical form Liquid
Storage Store in a cool, dry place away from moisture and incompatible materials

TFA should be stored in a cool, dry environment, away from moisture and incompatible substances to maintain its stability and effectiveness. It is recommended to use airtight containers made of materials resistant to strong acids, such as glass or high-density polyethylene. Due to its strong acidic nature, proper personal protective equipment, including gloves, goggles, and a lab coat, should always be worn when handling TFA. In case of spills, neutralizing agents should be used immediately to prevent damage to laboratory surfaces and equipment. Regular monitoring of storage conditions is essential to ensure the safety and integrity of the compound during long-term use.

References cited in the TCI brochure

  1. Alexander J. Rago. Di(2-picolyl)amines as Modular and Robust Ligands for Nickel-Catalyzed C(sp2)–C(sp3) Cross-Electrophile Coupling Organic Letters, 2022. doi:10.1021/acs.orglett.2c03346
  2. Eric C. Hansen. Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling The Journal of Organic Chemistry, 2017. doi:10.1021/acs.joc.7b01334

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