2-Thiopheneethanol TCI T1021

TCI T1021 2-Thiopheneethanol (CAS 5402-55-1) is a primary alcohol that contains a thiophene ring. A 2-hydroxyethyl group is attached at position 2 of this sulfur-containing heteroaromatic ring. The compound is classed as a heterocyclic building block, meaning a starting material used to assemble larger and more complex molecules. In synthetic chemistry, 2-thiopheneethanol is known as an important intermediate in the preparation of thienopyridine antiplatelet drugs such as ticlopidine and clopidogrel. In the laboratory it serves as a dependable entry point for heterocyclic synthesis projects.

The compound is a preferred choice because it offers two complementary reactive sites in a single molecule. The primary hydroxyl group is readily converted into a halide, a sulfonate, an aldehyde, or an ester, which gives chemists many ways to extend the side chain. The thiophene ring can undergo electrophilic substitution and cyclization reactions. Together, these features allow the construction of bicyclic thienopyridine frameworks and a wide range of other heterocyclic derivatives. Its liquid form also makes volumetric measurement convenient in laboratory-scale reactions.

For medicinal chemistry, pharmaceutical, and organic synthesis laboratories in Indonesia, 2-Thiopheneethanol is useful for researching synthetic routes to active pharmaceutical ingredients. It also supports the preparation of reference compounds and the development of new heterocyclic derivatives. The 25 mL pack suits research-scale work, where small, well-defined quantities are needed for method development and route scouting. Teams can use it to explore reaction conditions before committing to larger quantities of material.

• Thienopyridine drug intermediate research: the thiophene ring and the hydroxyethyl side chain are the structural elements used in routes toward antiplatelet agents such as ticlopidine and clopidogrel, so this compound suits route development studies.
• Conversion of the hydroxyl group: the primary alcohol is easily transformed into halides, sulfonates, aldehydes, or esters, which makes the compound a flexible starting point for building functionalized thiophene intermediates.
• Electrophilic substitution on the thiophene ring: the heteroaromatic ring can be functionalized further, so researchers can add substituents and tune the structure of new candidate molecules.
• Cyclization and bicyclic scaffold construction: the compound combines a reactive ring with a modifiable side chain, which supports the assembly of fused heterocyclic skeletons such as thienopyridines in synthesis research.
• Preparation of reference compounds and new heterocyclic derivatives: its liquid form allows convenient volumetric dosing, which helps laboratories prepare comparison standards and explore new derivatives in small, controlled batches.

• Product code: T1021

Store 2-Thiopheneethanol in its original tightly closed container, in a cool, dry, well-ventilated place away from direct sunlight, heat sources, and incompatible materials such as strong oxidizing agents. Follow the storage instructions on the TCI label and in the safety data sheet. Glass bottles with secure caps are suitable for keeping and transferring this liquid. When handling the compound, wear appropriate personal protective equipment, including safety glasses, gloves, and a laboratory coat. Work in a fume hood or a well-ventilated area, and avoid contact with skin and eyes and inhalation of vapors. Label any secondary containers clearly, and dispose of waste according to local regulations and institutional procedures.

—