Fluorinating Reagent to Convert Carboxyl Groups into Trifluoromethyl Groups (FLUOLEAD)
FLUOLEAD (4-tert-Butyl-2,6-dimethylphenylsulfur trifluoride, TCI code B3664) is a white crystalline solid used for fluorination of hydroxyl or carbonyl groups and for converting carboxyl groups into trifluoromethyl groups in good yields. Compared with DAST, it is less fuming and reacts slowly with water, so it is easier to handle in open air. It has high thermal stability, with a thermal decomposition temperature of 232 °C by DSC analysis, and can also fluorinate thioketones and thioesters. Fluorination of hydroxyl or carbonyl groups can be carried out over a broad reaction condition range of 0 to 100 °C.⁷)
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Download TCI brochure Fluorination Reagents, Fluorinated Building Blocks (PDF)
Source
- TCI Product Highlights: www.tcichemicals.com/ID/en/product/tci-topics/ProductHighlights_20241125
- TCI product page B1673: tcichemicals.com/ID/en/p/B1673
- TCI product page F0335: tcichemicals.com/ID/en/p/F0335
- TCI product page F1345: tcichemicals.com/ID/en/p/F1345
- TCI product page T1635: tcichemicals.com/ID/en/p/T1635
- TCI product page C2204: tcichemicals.com/ID/en/p/C2204
- TCI product page T2754: tcichemicals.com/ID/en/p/T2754
- TCI brochure R5051: Fluorination Reagents, Fluorinated Building Blocks
For research and laboratory use only, not for human consumption.
