Collection: Fluorinated Building Blocks

Fluorinated Building Blocks — contains building blocks bearing fluorine or trifluoromethyl groups, on both heterocyclic and non-heterocyclic frameworks, such as benzene derivatives, cyclohexane, and other aromatic compounds. This category provides a source of fluorine atoms for modifying the electronic properties and lipophilicity of target molecules.

These fluorinated building blocks are used in medicinal chemistry and materials science to incorporate trifluoromethyl or fluorine groups that affect metabolic stability and binding affinity in molecular design. Compounds such as bis(trifluoromethyl) derivatives and fluorinated nitrobenzene are also used as intermediates in stepwise synthesis toward complex aromatic structures.

Example products in this collection: TCI B1949 30071-93-3 3',5'-Bis(trifluoromethyl)acetophenone, TCI B5557 1637638-66-4 2-(tert-Butyldimethylsilyl)-1,3-phenylene Bis(trifluoromethanesulfonate), TCI B1751 401-95-6 3,5-Bis(trifluoromethyl)benzaldehyde, TCI B5645 79850-12-7 1,3-Bis(trifluoromethyl)cyclohexane (cis- and trans- mixture), TCI C2821 129825-11-2 4'-Chloro-3'-(trifluoromethyl)acetophenone, TCI B5646 433-18-1 1,4-Bis(trifluoromethyl)cyclohexane (cis- and trans- mixture), TCI A0377 393-11-3 5-Amino-2-nitrobenzotrifluoride, TCI B5688 345-24-4 1-Bromo-2,4-difluoro-5-nitrobenzene.

Pay attention to the position of fluorine substitution on the ring, the presence or absence of cis/trans isomer mixtures such as in difluorinated cyclohexane derivatives, as well as the purity and packaging format that suits your needs. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Building Blocks for Organic Synthesis, often used together in a single laboratory workflow:

• Non-Heterocyclic Building Blocks
• Heterocyclic Building Blocks
• Specialized Building Blocks for Drug Discovery

This collection is further divided into 2 more specific groups:

• Non-Heterocyclic Fluorinated Building Blocks
• Heterocyclic Fluorinated Building Blocks

Back to Building Blocks for Organic Synthesis. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.