Collection: 2'-O-Methylribonucleosides
2'-O-Methylribonucleosides — a collection of nucleosides with a methyl substitution at the 2'-O position of the ribose group, mimicking the natural methylation pattern found in cellular RNA. This modification changes the conformational stability of the sugar and affects how nucleic acid strands interact with enzymes and complementary strands.
2'-O-Methylribonucleosides are used as building blocks in the synthesis of modified oligonucleotides for epigenetics research, especially in studies of RNA methylation mechanisms and in designing antisense probes or siRNAs that are more stable against nuclease degradation. Molecular biology researchers use derivatives such as 2'-O-Methylguanosine, 2'-O-Methylcytidine, 2'-O-Methyladenosine, and 2'-O-Methyluridine to map natural modification sites in RNA and to design synthetic analogs with controlled hybridization properties.
Example products in this collection: TCI M2318 2140-71-8 2'-O-Methylguanosine, TCI M2290 2140-76-3 2'-O-Methyluridine, TCI M2317 2140-72-9 2'-O-Methylcytidine, TCI M2291 2140-79-6 2'-O-Methyladenosine.
Pay attention to nucleoside purity, the correct methylation position (2'-O, not the 3'-O isomer or other bases), and the physical form (dry powder) to suit further phosphoramidite synthesis. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.
Other categories at the same level under Epigenetics, often used together in one laboratory workflow:
Back to Epigenetics. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official TCI Japan distributor in Indonesia — for stock checks and lead times directly from Japan.
